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- W2947016168 abstract "The structure of promoter chromatin determines the ability of transcription factors (TFs) to bind to DNA and therefore has a profound effect on the expression levels of genes. However, the role of spontaneous nucleosome movements in this process is not fully understood. Here, we developed a single-molecule optical tweezers assay capable of simultaneously characterizing the base pair-scale diffusion of a nucleosome on DNA and the binding of a TF, using the luteinizing hormone β subunit gene (Lhb) promoter and Egr-1 as a model system. Our results demonstrate that nucleosomes undergo confined diffusion, and that the incorporation of the histone variant H2A.Z serves to partially relieve this confinement, inducing a different type of nucleosome repositioning. The increase in diffusion leads to exposure of a TF's binding site and facilitates its association with the DNA, which, in turn, biases the subsequent movement of the nucleosome. Our findings suggest the use of mobile nucleosomes as a general transcriptional regulatory mechanism." @default.
- W2947016168 created "2019-06-07" @default.
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- W2947016168 date "2019-05-30" @default.
- W2947016168 modified "2023-09-29" @default.
- W2947016168 title "The base pair-scale diffusion of nucleosomes modulates binding of transcription factors" @default.
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- W2947016168 doi "https://doi.org/10.1073/pnas.1815424116" @default.
- W2947016168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7056936" @default.
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