FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947020276> ?p ?o ?g. }

• W2947020276 abstract "The activation of neurohumoral compensatory mechanisms is a common physiological phenomenon in heart failure in order to make up for a failing heart, which will usually have a deteriorating effect on overall health condition. Many medications, such as neprilysin and angiotensin inhibitors, have recently been introduced to remediate neurohumoral changes. This study was conducted to evaluate the efficacy of the sacubitril-aliskiren combination versus the sacubitril-ramipril combination in the treatment of neurohumoral changes in rats with experimentally induced heart failure. Thirty Wister rats were randomly assigned into five groups each of six rats, the first group was the control group. Intraperitoneal isoprenaline injections of 5 mg/kg/day for 1 week were used to induce experimental models of heart failure in rats of the rest of experimental groups. The second group served as a positive control. Rats in the third, fourth, and fifth groups received oral daily dose of sacubitril 30 mg/kg/day, sacubitril-aliskiren 30,10 mg/kg/day, and sacubitril-ramipril 30/10 mg/kg/day respectively, for 2 weeks. Induction of heart failure in rats has significantly increased circulating NT-proBNP (980 ± 116.71 pg/ml), MMP9 (15.85 ± 0.57 ng/ml), troponin-I (3.09 ± 0.147 ng/ml), CK-MB (31.55 ± 1.69 ng/ml), renin (736 ± 45.8 pg/ml), urea (52.1 ± 1.57 mg/dl), and creatinine (0.92 ± 0.04 mg/dl). Significant decreases in glomerular filtration rate (7.031 ± 1.6 ml/hr./kg), urine flow (0.2761 ± 0.06 ml/h/kg), total solute excretion (0.11 ± 0.03 meq/m), and mean blood pressure (83.5 ± 2.6 mm hg) were seen in rats with heart failure. Rats treated with sacubitril combined with aliskiren or ramipril showed a statistically significant reduction of NT-proBNP, MMP9, troponin serum urea, and serum creatinine. Sacubitril-aliskiren or sacubitril-ramipril administration produced a significant increase in renin plasma level, total solute excretion, urine flow, and glomerular filtration rate. Sacubitril in combination with aliskiren or with ramipril effectively reduced plasma cardiac biomarkers, such as CK-MB, MMP9, and NT-proBNP, in rats with heart failure. Both combinations showed significant remediation of renal function through increasing GFR, urine flow, and total solute excretion, as well as reducing plasma level of renin. Net results revealed that the sacubitril-aliskiren combination has similar remediating effects on neurohumoral changes compared to the sacubitril-ramipril combination." @default.
• W2947020276 created "2019-06-07" @default.
• W2947020276 creator A5023712301 @default.
• W2947020276 creator A5063940209 @default.
• W2947020276 date "2019-05-03" @default.
• W2947020276 modified "2023-10-14" @default.
• W2947020276 title "Effects of neprilysin-renin inhibition in comparison with neprilysin-angiotensin inhibition on the neurohumoral changes in rats with heart failure" @default.
• W2947020276 cites W1911465839 @default.
• W2947020276 cites W1965257613 @default.
• W2947020276 cites W1981248368 @default.
• W2947020276 cites W1983183332 @default.
• W2947020276 cites W1996360780 @default.
• W2947020276 cites W2005035339 @default.
• W2947020276 cites W2035678180 @default.
• W2947020276 cites W2042687123 @default.
• W2947020276 cites W2044421924 @default.
• W2947020276 cites W2053164321 @default.
• W2947020276 cites W2117556875 @default.
• W2947020276 cites W2117877435 @default.
• W2947020276 cites W2119340816 @default.
• W2947020276 cites W2121754021 @default.
• W2947020276 cites W2123820140 @default.
• W2947020276 cites W2132777235 @default.
• W2947020276 cites W2135521686 @default.
• W2947020276 cites W2137323429 @default.
• W2947020276 cites W2154650976 @default.
• W2947020276 cites W2195459026 @default.
• W2947020276 cites W2205737835 @default.
• W2947020276 cites W2238377800 @default.
• W2947020276 cites W2782989835 @default.
• W2947020276 cites W2824562424 @default.
• W2947020276 doi "https://doi.org/10.1186/s40360-019-0304-z" @default.
• W2947020276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6500024" @default.
• W2947020276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31053170" @default.
• W2947020276 hasPublicationYear "2019" @default.
• W2947020276 type Work @default.
• W2947020276 sameAs 2947020276 @default.
• W2947020276 citedByCount "6" @default.
• W2947020276 countsByYear W29470202762019 @default.
• W2947020276 countsByYear W29470202762020 @default.
• W2947020276 countsByYear W29470202762021 @default.
• W2947020276 countsByYear W29470202762023 @default.
• W2947020276 crossrefType "journal-article" @default.
• W2947020276 hasAuthorship W2947020276A5023712301 @default.
• W2947020276 hasAuthorship W2947020276A5063940209 @default.
• W2947020276 hasBestOaLocation W29470202761 @default.
• W2947020276 hasConcept C104826730 @default.
• W2947020276 hasConcept C126322002 @default.
• W2947020276 hasConcept C134018914 @default.
• W2947020276 hasConcept C138976137 @default.
• W2947020276 hasConcept C159641895 @default.
• W2947020276 hasConcept C181199279 @default.
• W2947020276 hasConcept C185592680 @default.
• W2947020276 hasConcept C198710026 @default.
• W2947020276 hasConcept C2776754050 @default.
• W2947020276 hasConcept C2778198053 @default.
• W2947020276 hasConcept C2779838083 @default.
• W2947020276 hasConcept C2779888176 @default.
• W2947020276 hasConcept C55493867 @default.
• W2947020276 hasConcept C71924100 @default.
• W2947020276 hasConcept C78085059 @default.
• W2947020276 hasConcept C84393581 @default.
• W2947020276 hasConceptScore W2947020276C104826730 @default.
• W2947020276 hasConceptScore W2947020276C126322002 @default.
• W2947020276 hasConceptScore W2947020276C134018914 @default.
• W2947020276 hasConceptScore W2947020276C138976137 @default.
• W2947020276 hasConceptScore W2947020276C159641895 @default.
• W2947020276 hasConceptScore W2947020276C181199279 @default.
• W2947020276 hasConceptScore W2947020276C185592680 @default.
• W2947020276 hasConceptScore W2947020276C198710026 @default.
• W2947020276 hasConceptScore W2947020276C2776754050 @default.
• W2947020276 hasConceptScore W2947020276C2778198053 @default.
• W2947020276 hasConceptScore W2947020276C2779838083 @default.
• W2947020276 hasConceptScore W2947020276C2779888176 @default.
• W2947020276 hasConceptScore W2947020276C55493867 @default.
• W2947020276 hasConceptScore W2947020276C71924100 @default.
• W2947020276 hasConceptScore W2947020276C78085059 @default.
• W2947020276 hasConceptScore W2947020276C84393581 @default.
• W2947020276 hasIssue "1" @default.
• W2947020276 hasLocation W29470202761 @default.
• W2947020276 hasLocation W29470202762 @default.
• W2947020276 hasLocation W29470202763 @default.
• W2947020276 hasOpenAccess W2947020276 @default.
• W2947020276 hasPrimaryLocation W29470202761 @default.
• W2947020276 hasRelatedWork W2006078326 @default.
• W2947020276 hasRelatedWork W2052438865 @default.
• W2947020276 hasRelatedWork W2055451981 @default.
• W2947020276 hasRelatedWork W2091744418 @default.
• W2947020276 hasRelatedWork W2118772456 @default.
• W2947020276 hasRelatedWork W2124475604 @default.
• W2947020276 hasRelatedWork W2150378394 @default.
• W2947020276 hasRelatedWork W2157527675 @default.
• W2947020276 hasRelatedWork W2278230064 @default.
• W2947020276 hasRelatedWork W2920048038 @default.
• W2947020276 hasVolume "20" @default.
• W2947020276 isParatext "false" @default.
• W2947020276 isRetracted "false" @default.
• W2947020276 magId "2947020276" @default.
• W2947020276 workType "article" @default.