Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947020718> ?p ?o ?g. }
- W2947020718 abstract "Summary The WNT signaling network is comprised of multiple receptors that relay various input signals via distinct transduction pathways to execute multiple complex and context-specific output processes. Integrity of the WNT signaling network relies on proper specification between canonical and non-canonical pathways, which presents a regulatory challenge given that several signal transducing elements are shared between pathways. Here, we report that USP9X, a deubiquitylase, and WWP1, an E3 ubiquitin ligase, interact physically to regulate a ubiquitin switch on DVL2, a WNT signaling protein. Our findings indicate that USP9X-mediated deubiquitylation of DVL2 is required for canonical WNT activation, while DVL2 ubiquitylation promotes its localization to actin-rich projections and increased cellular motility. We propose that a WWP1-USP9X axis regulates a ubiquitin switch on DVL2 that specifies its participation in either canonical WNT or WNT-PCP pathways. These findings have important implications for therapeutic targeting of USP9X in human cancer." @default.
- W2947020718 created "2019-06-07" @default.
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- W2947020718 date "2018-03-27" @default.
- W2947020718 modified "2023-09-26" @default.
- W2947020718 title "USP9X regulates DVL2 ubiquitylation to determine WNT pathway specification" @default.
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- W2947020718 doi "https://doi.org/10.1101/289595" @default.
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