Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947047105> ?p ?o ?g. }
- W2947047105 endingPage "4093" @default.
- W2947047105 startingPage "4082" @default.
- W2947047105 abstract "BACKGROUND Alzheimer's disease (AD) is an age-associated neurodegenerative disorder. This study aimed to investigate effects of acupuncture administration on cognitive function and associated mechanisms. MATERIAL AND METHODS Senescence-accelerated prone 8 (SAM-P8) mice were randomly divided into 3 groups: the SAM-P8 group (P8-CN), the SAM-P8 administrating with acupuncture (P8-Acup) group, and the SAM-P8 administrating without acupuncture (P8-Sham) group. Morris water maze test was conducted to evaluate cognitive functions (memory and learning ability). PDK1, nPKC, and Rac1 inhibitors were used to treat SAM-P8 mice. Transmission electron microscope analysis was used to examine nuclear damage hippocampal tissues. Hematoxylin and eosin (H&E) staining was employed to evaluate inflammation. Western blot was used to detect PI3K, PDK1, nPKC, and Rac 1 expression in hippocampal tissues. RESULTS Acupuncture administration significantly reduced PI3K, PDK1, nPKC, and Rac 1 levels compared to P8-CN group (P<0.05). Both acupuncture and enzyme inhibitors (NSC23766, Rottlerin, OSU03012) significantly improved cognitive functions, reduced inflammation, and alleviated nuclear damages of SAM-P8 mice compared to P8-CN group (P<0.05). Acupuncture significantly enhanced effects of inhibitors on inflammation and nuclear damages compared to inhibitor treatment single (P<0.05). Acupuncture significantly enhanced down-regulative effects of OSU03012 on PI3K and PDK1 levels, increased down-regulative effects of Rottlerin on nPKC and Rac 1 levels and enhanced effects of Rottlerin on Rac 1 compared to P8-CN group (P<0.05). CONCLUSIONS Acupuncture administration improved cognitive functions and alleviated inflammatory response and nuclear damage of SAM-P8 mice, by downregulating PI3K/PDK1/nPKC/Rac 1 signaling pathway. This study could provide potential insight for treating cognitive dysfunction and aging of AD patients." @default.
- W2947047105 created "2019-06-07" @default.
- W2947047105 creator A5005905613 @default.
- W2947047105 creator A5007038205 @default.
- W2947047105 creator A5013273035 @default.
- W2947047105 creator A5046906321 @default.
- W2947047105 creator A5056116729 @default.
- W2947047105 creator A5090050137 @default.
- W2947047105 date "2019-06-01" @default.
- W2947047105 modified "2023-10-13" @default.
- W2947047105 title "Acupuncture Administration Improves Cognitive Functions and Alleviates Inflammation and Nuclear Damage by Regulating Phosphatidylinositol 3 Kinase (PI3K)/Phosphoinositol-Dependent Kinase 1 (PDK1)/Novel Protein Kinase C (nPKC)/Rac 1 Signaling Pathway in Senescence-Accelerated Prone 8 (SAM-P8) Mice" @default.
- W2947047105 cites W1504048462 @default.
- W2947047105 cites W1969476369 @default.
- W2947047105 cites W1974790839 @default.
- W2947047105 cites W1984653051 @default.
- W2947047105 cites W1992751298 @default.
- W2947047105 cites W2031927749 @default.
- W2947047105 cites W2062240162 @default.
- W2947047105 cites W2080946103 @default.
- W2947047105 cites W2088343957 @default.
- W2947047105 cites W2094256272 @default.
- W2947047105 cites W2101741807 @default.
- W2947047105 cites W2102182027 @default.
- W2947047105 cites W2124569584 @default.
- W2947047105 cites W2131391680 @default.
- W2947047105 cites W2136097257 @default.
- W2947047105 cites W2136765652 @default.
- W2947047105 cites W2148205722 @default.
- W2947047105 cites W2148905449 @default.
- W2947047105 cites W2151012511 @default.
- W2947047105 cites W2200412264 @default.
- W2947047105 cites W234565542 @default.
- W2947047105 cites W2407948051 @default.
- W2947047105 cites W2520652717 @default.
- W2947047105 cites W2544972874 @default.
- W2947047105 cites W2553774099 @default.
- W2947047105 cites W2584298660 @default.
- W2947047105 cites W2589961611 @default.
- W2947047105 cites W2746376334 @default.
- W2947047105 cites W2762286068 @default.
- W2947047105 cites W2767724659 @default.
- W2947047105 cites W2777267448 @default.
- W2947047105 cites W2779376601 @default.
- W2947047105 cites W2786263204 @default.
- W2947047105 cites W2787534243 @default.
- W2947047105 cites W2790460340 @default.
- W2947047105 cites W2792127134 @default.
- W2947047105 cites W2794103257 @default.
- W2947047105 cites W2801275144 @default.
- W2947047105 cites W2801948587 @default.
- W2947047105 cites W2802170692 @default.
- W2947047105 cites W2802909891 @default.
- W2947047105 cites W2887651840 @default.
- W2947047105 cites W2953191221 @default.
- W2947047105 cites W2982521784 @default.
- W2947047105 cites W344771105 @default.
- W2947047105 cites W656779167 @default.
- W2947047105 doi "https://doi.org/10.12659/msm.913858" @default.
- W2947047105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6559003" @default.
- W2947047105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31152645" @default.
- W2947047105 hasPublicationYear "2019" @default.
- W2947047105 type Work @default.
- W2947047105 sameAs 2947047105 @default.
- W2947047105 citedByCount "13" @default.
- W2947047105 countsByYear W29470471052020 @default.
- W2947047105 countsByYear W29470471052022 @default.
- W2947047105 countsByYear W29470471052023 @default.
- W2947047105 crossrefType "journal-article" @default.
- W2947047105 hasAuthorship W2947047105A5005905613 @default.
- W2947047105 hasAuthorship W2947047105A5007038205 @default.
- W2947047105 hasAuthorship W2947047105A5013273035 @default.
- W2947047105 hasAuthorship W2947047105A5046906321 @default.
- W2947047105 hasAuthorship W2947047105A5056116729 @default.
- W2947047105 hasAuthorship W2947047105A5090050137 @default.
- W2947047105 hasBestOaLocation W29470471052 @default.
- W2947047105 hasConcept C104317684 @default.
- W2947047105 hasConcept C126322002 @default.
- W2947047105 hasConcept C134018914 @default.
- W2947047105 hasConcept C142724271 @default.
- W2947047105 hasConcept C184235292 @default.
- W2947047105 hasConcept C185592680 @default.
- W2947047105 hasConcept C204787440 @default.
- W2947047105 hasConcept C2776202274 @default.
- W2947047105 hasConcept C2776415932 @default.
- W2947047105 hasConcept C2776914184 @default.
- W2947047105 hasConcept C2778769476 @default.
- W2947047105 hasConcept C2781161787 @default.
- W2947047105 hasConcept C44752575 @default.
- W2947047105 hasConcept C55493867 @default.
- W2947047105 hasConcept C56837625 @default.
- W2947047105 hasConcept C62478195 @default.
- W2947047105 hasConcept C71924100 @default.
- W2947047105 hasConcept C86554907 @default.
- W2947047105 hasConcept C97029542 @default.
- W2947047105 hasConcept C98274493 @default.
- W2947047105 hasConceptScore W2947047105C104317684 @default.
- W2947047105 hasConceptScore W2947047105C126322002 @default.
- W2947047105 hasConceptScore W2947047105C134018914 @default.