Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947065889> ?p ?o ?g. }
- W2947065889 endingPage "10862" @default.
- W2947065889 startingPage "10846" @default.
- W2947065889 abstract "Cell migration is essential to embryonic development, wound healing, and cancer cell dissemination. Cells move via leading-edge protrusion, substrate adhesion, and retraction of the cell's rear. The molecular mechanisms by which extracellular cues signal to the actomyosin cytoskeleton to control these motility mechanics are poorly understood. The growth factor-responsive and oncogenically activated protein extracellular signal-regulated kinase (ERK) promotes motility by signaling in actin polymerization-mediated edge protrusion. Using a combination of immunoblotting, co-immunoprecipitation, and myosin-binding experiments and cell migration assays, we show here that ERK also signals to the contractile machinery through its substrate, p90 ribosomal S6 kinase (RSK). We probed the signaling and migration dynamics of multiple mammalian cell lines and found that RSK phosphorylates myosin phosphatase–targeting subunit 1 (MYPT1) at Ser-507, which promotes an interaction of Rho kinase (ROCK) with MYPT1 and inhibits myosin targeting. We find that by inhibiting the myosin phosphatase, ERK and RSK promote myosin II–mediated tension for lamella expansion and optimal edge dynamics for cell migration. These findings suggest that ERK activity can coordinately amplify both protrusive and contractile forces for optimal cell motility." @default.
- W2947065889 created "2019-06-07" @default.
- W2947065889 creator A5002793518 @default.
- W2947065889 creator A5006515433 @default.
- W2947065889 creator A5019076582 @default.
- W2947065889 creator A5029537789 @default.
- W2947065889 creator A5041339079 @default.
- W2947065889 creator A5055363313 @default.
- W2947065889 creator A5074254415 @default.
- W2947065889 creator A5075201122 @default.
- W2947065889 date "2019-07-01" @default.
- W2947065889 modified "2023-10-17" @default.
- W2947065889 title "p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration" @default.
- W2947065889 cites W1088509254 @default.
- W2947065889 cites W1518252063 @default.
- W2947065889 cites W1601455272 @default.
- W2947065889 cites W1905742426 @default.
- W2947065889 cites W1964961398 @default.
- W2947065889 cites W1967229546 @default.
- W2947065889 cites W1967265143 @default.
- W2947065889 cites W1968629035 @default.
- W2947065889 cites W1968809812 @default.
- W2947065889 cites W1969785844 @default.
- W2947065889 cites W1971106165 @default.
- W2947065889 cites W1977672499 @default.
- W2947065889 cites W1981127684 @default.
- W2947065889 cites W1985502400 @default.
- W2947065889 cites W1987139499 @default.
- W2947065889 cites W1987966101 @default.
- W2947065889 cites W1988797182 @default.
- W2947065889 cites W1990127032 @default.
- W2947065889 cites W1992746048 @default.
- W2947065889 cites W1997087774 @default.
- W2947065889 cites W1998203489 @default.
- W2947065889 cites W2005971493 @default.
- W2947065889 cites W2006591686 @default.
- W2947065889 cites W2010700971 @default.
- W2947065889 cites W2012354170 @default.
- W2947065889 cites W2015714994 @default.
- W2947065889 cites W2023446937 @default.
- W2947065889 cites W2025872894 @default.
- W2947065889 cites W2030029307 @default.
- W2947065889 cites W2030705338 @default.
- W2947065889 cites W2032295238 @default.
- W2947065889 cites W2034082312 @default.
- W2947065889 cites W2034210044 @default.
- W2947065889 cites W2038695324 @default.
- W2947065889 cites W2038870603 @default.
- W2947065889 cites W2038873938 @default.
- W2947065889 cites W2042015318 @default.
- W2947065889 cites W2042625441 @default.
- W2947065889 cites W2043274355 @default.
- W2947065889 cites W2045424472 @default.
- W2947065889 cites W2046783870 @default.
- W2947065889 cites W2048209624 @default.
- W2947065889 cites W2048702755 @default.
- W2947065889 cites W2049967046 @default.
- W2947065889 cites W2050573392 @default.
- W2947065889 cites W2051549807 @default.
- W2947065889 cites W2052615604 @default.
- W2947065889 cites W2052771249 @default.
- W2947065889 cites W2054590902 @default.
- W2947065889 cites W2055380229 @default.
- W2947065889 cites W2056563854 @default.
- W2947065889 cites W2058258724 @default.
- W2947065889 cites W2060545109 @default.
- W2947065889 cites W2064854415 @default.
- W2947065889 cites W2066217899 @default.
- W2947065889 cites W2066700256 @default.
- W2947065889 cites W2076073423 @default.
- W2947065889 cites W2079595896 @default.
- W2947065889 cites W2080692619 @default.
- W2947065889 cites W2083307291 @default.
- W2947065889 cites W2085037886 @default.
- W2947065889 cites W2089920144 @default.
- W2947065889 cites W2094588591 @default.
- W2947065889 cites W2098159442 @default.
- W2947065889 cites W2105029267 @default.
- W2947065889 cites W2105094145 @default.
- W2947065889 cites W2109706035 @default.
- W2947065889 cites W2111719518 @default.
- W2947065889 cites W2117273462 @default.
- W2947065889 cites W2117395405 @default.
- W2947065889 cites W2126496496 @default.
- W2947065889 cites W2127611014 @default.
- W2947065889 cites W2128762961 @default.
- W2947065889 cites W2129464501 @default.
- W2947065889 cites W2130963215 @default.
- W2947065889 cites W2134342926 @default.
- W2947065889 cites W2134848551 @default.
- W2947065889 cites W2138231208 @default.
- W2947065889 cites W2146047000 @default.
- W2947065889 cites W2148454908 @default.
- W2947065889 cites W2150301412 @default.
- W2947065889 cites W2151878020 @default.
- W2947065889 cites W2152086488 @default.
- W2947065889 cites W2159325467 @default.
- W2947065889 cites W2160923835 @default.