Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947069061> ?p ?o ?g. }
- W2947069061 abstract "Neonatal seizures are different from adult seizures, and many antiepileptic drugs that are effective in adults often fail to treat neonates. Here, we report that gluconate inhibits neonatal seizure by inhibiting CLC-3 chloride channels. We detect a voltage-dependent outward rectifying Cl− current mediated by CLC-3 Cl− channels in early developing brains but not adult mouse brains. Blocking CLC-3 Cl− channels by gluconate inhibits seizure activity both in neonatal brain slices and in neonatal animals with in vivo EEG recordings. Consistently, neonatal neurons of CLC-3 knockout mice lack the outward rectifying Cl− current and show reduced epileptiform activity upon stimulation. Mechanistically, we demonstrate that activation of CLC-3 Cl− channels alters intracellular Cl− homeostasis and enhances GABA excitatory activity. Our studies suggest that gluconate can suppress neonatal seizure activities through inhibiting CLC-3 Cl− channels in developing brains." @default.
- W2947069061 created "2019-06-07" @default.
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- W2947069061 date "2019-05-15" @default.
- W2947069061 modified "2023-09-26" @default.
- W2947069061 title "Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels" @default.
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- W2947069061 doi "https://doi.org/10.1186/s13041-019-0465-0" @default.
- W2947069061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6518791" @default.
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