FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947069657> ?p ?o ?g. }

• W2947069657 endingPage "122" @default.
• W2947069657 startingPage "115" @default.
• W2947069657 abstract "Beta-lactamase (EC 3.5.2.6) synthesis, particularly in Gram-negative bacilli, is a major mechanism of natural and acquired resistance to beta-lactams, sometimes accompanied by impermeability and/or active efflux. These enzymes have been classified into four molecular classes (A-D). The serine enzymes of class A, which may be encoded by the bacterial chromosome or transferable elements and are susceptible to clinically available inhibitors (clavulanic acid, sulbactam, tazobactam, avibactam), are prevalent considering other molecular classes (B,C,D). The continual rapid development of genomic approaches and tremendous progress in automatic sequencer technology have resulted in the accumulation of massive amounts of data. A structure-based classification of class A beta-lactamases based on specific conserved motifs involved in catalytic mechanisms and/or substrate binding (S70XXK, S130DN, K234TG), together with E166 (Ambler numbering) and at least 24 other amino-acid residues or analogs such as G45, F66, V80, L81, L91, L101, P107, A134, L138, G143, G144, G156, L169, T181, T182, P183, was validated on 700 amino-acid sequences, including 132 representative types, but mostly probable enzyme sequences, many produced by environmental bacteria. Two subclasses (A1, A2), six major clusters or groups (e.g. natural limited-spectrum beta-lactamases (LSBL), wider spectrum beta-lactamases (WSBL), and various other clusters were identified on the basis of conserved (> 90%) and specific motifs, and residues such as S70TFKAL, S130DNTAANL, R164XEXXLN, V231GDKTG for subclass A1, S70VFKFH, S130DNNACDI,E166XXM, and V231AHKTG for subclass A2, a probable disulfide bridge C77-C123 and G236, A237, G238, and R244 for the LSBL group. This great diversity of primary structures was used as the basis for a structure-based and phylogenetic classification." @default.
• W2947069657 created "2019-06-07" @default.
• W2947069657 creator A5003501683 @default.
• W2947069657 creator A5022157667 @default.
• W2947069657 creator A5039167366 @default.
• W2947069657 creator A5051267142 @default.
• W2947069657 date "2019-11-01" @default.
• W2947069657 modified "2023-10-18" @default.
• W2947069657 title "Structure-based classification of class A beta-lactamases, an update" @default.
• W2947069657 cites W1536681123 @default.
• W2947069657 cites W1701997017 @default.
• W2947069657 cites W1825991320 @default.
• W2947069657 cites W1861263514 @default.
• W2947069657 cites W1902535075 @default.
• W2947069657 cites W1907651016 @default.
• W2947069657 cites W1944210195 @default.
• W2947069657 cites W1948084058 @default.
• W2947069657 cites W1959276598 @default.
• W2947069657 cites W1968289532 @default.
• W2947069657 cites W1970559386 @default.
• W2947069657 cites W1978212838 @default.
• W2947069657 cites W1980290170 @default.
• W2947069657 cites W1983186463 @default.
• W2947069657 cites W1986463813 @default.
• W2947069657 cites W1990039085 @default.
• W2947069657 cites W2000205868 @default.
• W2947069657 cites W2000426919 @default.
• W2947069657 cites W2014857872 @default.
• W2947069657 cites W2023678813 @default.
• W2947069657 cites W2039952979 @default.
• W2947069657 cites W2044043800 @default.
• W2947069657 cites W2073703928 @default.
• W2947069657 cites W2086685399 @default.
• W2947069657 cites W2088608223 @default.
• W2947069657 cites W2101485338 @default.
• W2947069657 cites W2104581102 @default.
• W2947069657 cites W2117992091 @default.
• W2947069657 cites W2120209793 @default.
• W2947069657 cites W2120772351 @default.
• W2947069657 cites W2121254474 @default.
• W2947069657 cites W2123677996 @default.
• W2947069657 cites W2127322768 @default.
• W2947069657 cites W2132957182 @default.
• W2947069657 cites W2134352676 @default.
• W2947069657 cites W2136437790 @default.
• W2947069657 cites W2139147280 @default.
• W2947069657 cites W2140959622 @default.
• W2947069657 cites W2143165503 @default.
• W2947069657 cites W2146097635 @default.
• W2947069657 cites W2152127318 @default.
• W2947069657 cites W2154337802 @default.
• W2947069657 cites W2162755780 @default.
• W2947069657 cites W2179733851 @default.
• W2947069657 cites W2203363469 @default.
• W2947069657 cites W2214286466 @default.
• W2947069657 cites W2237445887 @default.
• W2947069657 cites W2274153833 @default.
• W2947069657 cites W2293828825 @default.
• W2947069657 cites W2374021734 @default.
• W2947069657 cites W2399835226 @default.
• W2947069657 cites W2469861444 @default.
• W2947069657 cites W2472548405 @default.
• W2947069657 cites W2474189924 @default.
• W2947069657 cites W2489287057 @default.
• W2947069657 cites W2508936338 @default.
• W2947069657 cites W2528719882 @default.
• W2947069657 cites W2531758255 @default.
• W2947069657 cites W2556334527 @default.
• W2947069657 cites W2558190914 @default.
• W2947069657 cites W2576373510 @default.
• W2947069657 cites W2582308676 @default.
• W2947069657 cites W2586552239 @default.
• W2947069657 cites W2589345399 @default.
• W2947069657 cites W2591209965 @default.
• W2947069657 cites W2606700140 @default.
• W2947069657 cites W2618969540 @default.
• W2947069657 cites W2724833747 @default.
• W2947069657 cites W2737879351 @default.
• W2947069657 cites W2745203218 @default.
• W2947069657 cites W2746410186 @default.
• W2947069657 cites W2749021949 @default.
• W2947069657 cites W2751923859 @default.
• W2947069657 cites W2754206640 @default.
• W2947069657 cites W2767482081 @default.
• W2947069657 cites W2776368375 @default.
• W2947069657 cites W2790965800 @default.
• W2947069657 cites W2883735775 @default.
• W2947069657 cites W2884524290 @default.
• W2947069657 cites W2891518412 @default.
• W2947069657 cites W2918608884 @default.
• W2947069657 cites W2951086309 @default.
• W2947069657 cites W4211093779 @default.
• W2947069657 doi "https://doi.org/10.1016/j.retram.2019.05.003" @default.
• W2947069657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31155436" @default.
• W2947069657 hasPublicationYear "2019" @default.
• W2947069657 type Work @default.
• W2947069657 sameAs 2947069657 @default.
• W2947069657 citedByCount "16" @default.

• next