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- W2947086105 abstract "Retrotransposons are the major determinants of genome sizes and they have shaped both genes and genomes in mammalian organisms, but their overall activity, diversity, and evolution dynamics, particularly their impact on protein coding and lncRNA genes in pigs remain largely unknown. In the present study, we performed de novo detection of retrotransposons in pigs by using multiple pipelines, four distinct families of pig-specific L1 s classified into 51 distinct subfamilies and representing four evolution models and three expansion waves of pig-specific SINEs represented by three distinct families were identified. ERVs were classified into 18 families and found two most “modern” subfamilies in the pig genome. The transposition activity of pig L1 was verified by experiment, the sense and antisense promoter activities of young L1 5′UTRs and ERV LTRs and expression profiles of young retrotransposons in multiple tissues and cell lines were also validated. Furthermore, retrotransposons had an extensive impact on lncRNA and protein coding genes at both the genomic and transcriptomic levels. Most protein coding and lncRNA (> 80%) genes contained retrotransposon insertions, and about half of protein coding genes (44.30%) and one-fourth (24.13%) of lncRNA genes contained the youngest retrotransposon insertions. Nearly half of protein coding genes (43.78%) could generate chimeric transcripts with retrotransposons. Significant distribution bias of retrotransposon composition, location, and orientation in lncRNA and protein coding genes, and their transcripts, were observed. In the current study, we characterized the classification and evolution profile of retrotransposons in pigs, experimentally proved the transposition activity of the young pig L1 subfamily, characterized the sense and antisense expression profiles and promoter activities of young retrotransposons, and investigated their impact on lncRNA and protein coding genes by defining the mobilome landscapes at the genomic and transcriptomic levels. These findings help provide a better understanding of retrotransposon evolution in mammal and their impact on the genome and transcriptome." @default.
- W2947086105 created "2019-06-07" @default.
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- W2947086105 date "2019-05-06" @default.
- W2947086105 modified "2023-10-17" @default.
- W2947086105 title "Retrotransposons evolution and impact on lncRNA and protein coding genes in pigs" @default.
- W2947086105 cites W1412166937 @default.
- W2947086105 cites W1514569936 @default.
- W2947086105 cites W1527051479 @default.
- W2947086105 cites W1590271440 @default.
- W2947086105 cites W1651738511 @default.
- W2947086105 cites W176539372 @default.
- W2947086105 cites W1934547378 @default.
- W2947086105 cites W1964486213 @default.
- W2947086105 cites W1965408671 @default.
- W2947086105 cites W1974134624 @default.
- W2947086105 cites W1978353478 @default.
- W2947086105 cites W1980577355 @default.
- W2947086105 cites W1985582783 @default.
- W2947086105 cites W1985714764 @default.
- W2947086105 cites W1988670848 @default.
- W2947086105 cites W1995311901 @default.
- W2947086105 cites W1996429296 @default.
- W2947086105 cites W1997758697 @default.
- W2947086105 cites W1998390679 @default.
- W2947086105 cites W1999341805 @default.
- W2947086105 cites W1999930403 @default.
- W2947086105 cites W2001806616 @default.
- W2947086105 cites W2004284284 @default.
- W2947086105 cites W2014704298 @default.
- W2947086105 cites W2029868997 @default.
- W2947086105 cites W2041988826 @default.
- W2947086105 cites W2042086471 @default.
- W2947086105 cites W2044993762 @default.
- W2947086105 cites W2047285578 @default.
- W2947086105 cites W2047648048 @default.
- W2947086105 cites W2050557699 @default.
- W2947086105 cites W2050669549 @default.
- W2947086105 cites W2054254276 @default.
- W2947086105 cites W2059864757 @default.
- W2947086105 cites W2062098224 @default.
- W2947086105 cites W2065461553 @default.
- W2947086105 cites W2068405192 @default.
- W2947086105 cites W2069384396 @default.
- W2947086105 cites W2070937455 @default.
- W2947086105 cites W2074813718 @default.
- W2947086105 cites W2075231789 @default.
- W2947086105 cites W2086739233 @default.
- W2947086105 cites W2105647896 @default.
- W2947086105 cites W2107333779 @default.
- W2947086105 cites W2107454957 @default.
- W2947086105 cites W2111203527 @default.
- W2947086105 cites W2111400550 @default.
- W2947086105 cites W2113324240 @default.
- W2947086105 cites W2113636307 @default.
- W2947086105 cites W2113685335 @default.
- W2947086105 cites W2115759508 @default.
- W2947086105 cites W2115809399 @default.
- W2947086105 cites W2119996990 @default.
- W2947086105 cites W2123543493 @default.
- W2947086105 cites W2127469308 @default.
- W2947086105 cites W2129548171 @default.
- W2947086105 cites W2134026743 @default.
- W2947086105 cites W2134520741 @default.
- W2947086105 cites W2136145671 @default.
- W2947086105 cites W2136788904 @default.
- W2947086105 cites W2137015675 @default.
- W2947086105 cites W2137455182 @default.
- W2947086105 cites W2139088348 @default.
- W2947086105 cites W2139367243 @default.
- W2947086105 cites W2142805668 @default.
- W2947086105 cites W2144216698 @default.
- W2947086105 cites W2151464048 @default.
- W2947086105 cites W2151464330 @default.
- W2947086105 cites W2152222332 @default.
- W2947086105 cites W2152369882 @default.
- W2947086105 cites W2152882637 @default.
- W2947086105 cites W2158126340 @default.
- W2947086105 cites W2163091657 @default.
- W2947086105 cites W2163600777 @default.
- W2947086105 cites W2166605725 @default.
- W2947086105 cites W2168909179 @default.
- W2947086105 cites W2170581254 @default.
- W2947086105 cites W2171095250 @default.
- W2947086105 cites W2187437779 @default.
- W2947086105 cites W2196440573 @default.
- W2947086105 cites W2262482817 @default.
- W2947086105 cites W2263391408 @default.
- W2947086105 cites W2311203695 @default.
- W2947086105 cites W2321890835 @default.