FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947098535> ?p ?o ?g. }

• W2947098535 endingPage "20190800" @default.
• W2947098535 startingPage "20190800" @default.
• W2947098535 abstract "Telomere length (TL) declines with age in most human tissues, and shorter TL appears to accelerate senescence. By contrast, men's sperm TL is positively correlated with age. Correspondingly, in humans, older paternal age at conception (PAC) predicts longer offspring TL. We have hypothesized that this PAC effect could persist across multiple generations, and thereby contribute to a transgenerational genetic plasticity that increases expenditures on somatic maintenance as the average age at reproduction is delayed within a lineage. Here, we examine TL data from 3282 humans together with PAC data across four generations. In this sample, the PAC effect is detectable in children and grandchildren. The PAC effect is transmitted through the matriline and patriline with similar strength and is characterized by a generational decay. PACs of more distant male ancestors were not significant predictors, although statistical power was limited in these analyses. Sensitivity analyses suggest that the PAC effect is linear, not moderated by offspring age, or maternal age, and is robust to controls for income, urbanicity and ancestry. These findings show that TL reflects the age at the reproduction of recent male matrilineal and patrilineal ancestors, with an effect that decays across generations." @default.
• W2947098535 created "2019-06-07" @default.
• W2947098535 creator A5017820742 @default.
• W2947098535 creator A5050063668 @default.
• W2947098535 creator A5058712904 @default.
• W2947098535 creator A5087278865 @default.
• W2947098535 creator A5089858670 @default.
• W2947098535 date "2019-05-29" @default.
• W2947098535 modified "2023-10-11" @default.
• W2947098535 title "Older paternal ages and grandpaternal ages at conception predict longer telomeres in human descendants" @default.
• W2947098535 cites W1483456062 @default.
• W2947098535 cites W1790414662 @default.
• W2947098535 cites W1847536967 @default.
• W2947098535 cites W1983673827 @default.
• W2947098535 cites W2040466227 @default.
• W2947098535 cites W2058868281 @default.
• W2947098535 cites W2067308958 @default.
• W2947098535 cites W2104330570 @default.
• W2947098535 cites W2106268089 @default.
• W2947098535 cites W2152588928 @default.
• W2947098535 cites W2163825087 @default.
• W2947098535 cites W2282291095 @default.
• W2947098535 cites W2312884820 @default.
• W2947098535 cites W2336501432 @default.
• W2947098535 cites W2508539499 @default.
• W2947098535 cites W2582201920 @default.
• W2947098535 cites W2755091369 @default.
• W2947098535 cites W2765441353 @default.
• W2947098535 cites W2777227069 @default.
• W2947098535 cites W2789232920 @default.
• W2947098535 cites W2790462104 @default.
• W2947098535 cites W2892804608 @default.
• W2947098535 cites W2909039941 @default.
• W2947098535 cites W2914640889 @default.
• W2947098535 doi "https://doi.org/10.1098/rspb.2019.0800" @default.
• W2947098535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6545073" @default.
• W2947098535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31138065" @default.
• W2947098535 hasPublicationYear "2019" @default.
• W2947098535 type Work @default.
• W2947098535 sameAs 2947098535 @default.
• W2947098535 citedByCount "19" @default.
• W2947098535 countsByYear W29470985352019 @default.
• W2947098535 countsByYear W29470985352020 @default.
• W2947098535 countsByYear W29470985352021 @default.
• W2947098535 countsByYear W29470985352022 @default.
• W2947098535 countsByYear W29470985352023 @default.
• W2947098535 crossrefType "journal-article" @default.
• W2947098535 hasAuthorship W2947098535A5017820742 @default.
• W2947098535 hasAuthorship W2947098535A5050063668 @default.
• W2947098535 hasAuthorship W2947098535A5058712904 @default.
• W2947098535 hasAuthorship W2947098535A5087278865 @default.
• W2947098535 hasAuthorship W2947098535A5089858670 @default.
• W2947098535 hasBestOaLocation W29470985351 @default.
• W2947098535 hasConcept C104317684 @default.
• W2947098535 hasConcept C112672928 @default.
• W2947098535 hasConcept C144024400 @default.
• W2947098535 hasConcept C149923435 @default.
• W2947098535 hasConcept C177336024 @default.
• W2947098535 hasConcept C184151982 @default.
• W2947098535 hasConcept C2779234561 @default.
• W2947098535 hasConcept C522857546 @default.
• W2947098535 hasConcept C54355233 @default.
• W2947098535 hasConcept C59659247 @default.
• W2947098535 hasConcept C78458016 @default.
• W2947098535 hasConcept C86803240 @default.
• W2947098535 hasConceptScore W2947098535C104317684 @default.
• W2947098535 hasConceptScore W2947098535C112672928 @default.
• W2947098535 hasConceptScore W2947098535C144024400 @default.
• W2947098535 hasConceptScore W2947098535C149923435 @default.
• W2947098535 hasConceptScore W2947098535C177336024 @default.
• W2947098535 hasConceptScore W2947098535C184151982 @default.
• W2947098535 hasConceptScore W2947098535C2779234561 @default.
• W2947098535 hasConceptScore W2947098535C522857546 @default.
• W2947098535 hasConceptScore W2947098535C54355233 @default.
• W2947098535 hasConceptScore W2947098535C59659247 @default.
• W2947098535 hasConceptScore W2947098535C78458016 @default.
• W2947098535 hasConceptScore W2947098535C86803240 @default.
• W2947098535 hasFunder F4320306550 @default.
• W2947098535 hasIssue "1903" @default.
• W2947098535 hasLocation W29470985351 @default.
• W2947098535 hasLocation W29470985352 @default.
• W2947098535 hasLocation W29470985353 @default.
• W2947098535 hasLocation W29470985354 @default.
• W2947098535 hasOpenAccess W2947098535 @default.
• W2947098535 hasPrimaryLocation W29470985351 @default.
• W2947098535 hasRelatedWork W1972137225 @default.
• W2947098535 hasRelatedWork W2084255033 @default.
• W2947098535 hasRelatedWork W2088926897 @default.
• W2947098535 hasRelatedWork W2109961065 @default.
• W2947098535 hasRelatedWork W2371502216 @default.
• W2947098535 hasRelatedWork W2461096401 @default.
• W2947098535 hasRelatedWork W2598831616 @default.
• W2947098535 hasRelatedWork W2963695449 @default.
• W2947098535 hasRelatedWork W4249346855 @default.
• W2947098535 hasRelatedWork W4323767847 @default.
• W2947098535 hasVolume "286" @default.
• W2947098535 isParatext "false" @default.
• W2947098535 isRetracted "false" @default.

• next