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- W2947105704 abstract "e18006 Background: Clinical trial enrollment is an assiduous process and requires active initiation and maintenance efforts by providers, patients, trial investigators, or other clinical staff. Setting up automated process triggers to perform a reflex clinical trial matching can kick-start the process without requiring human intervention. Methods: Using a clinical trial matching service developed in collaboration with GenomOncology, we used the receipt of sequencing test results as a process trigger to perform reflex clinical trial matching on oncology patients. A research nurse performed additional refinements to these results using multi-faceted filtering and an initial manual prescreening. In this pragmatic study, providers were randomized to receive results of prescreening events. EMR messages were sent to the intervention cohort of providers with recommendations for clinical trials for their patients and suggested next steps. Provider responses and prescreening outcomes were recorded in a REDCap project. To iteratively refine the trial results, matching algorithm updates were deployed throughout the study. Results: In the pilot deployment of this trial, we performed prescreening on 60 patients. At the time of prescreening vital status of 17% of the patients was outdated. We observed that trial cohort related recruiting statuses were the highest contributors to false matches (44%) and provider response rate was 94%. Conclusions: It is not possible to make substantial improvements to the outcome of clinical trial enrollment events without investing in reliable publicly available resources that host updated recruiting status for trials at the arm/cohort level. Uptake of such efforts by NCI or NLM has the potential to radically change the accuracy of clinical trial matching services and thereby improve enrollment efficiencies.[Table: see text]" @default.
- W2947105704 created "2019-06-07" @default.
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- W2947105704 date "2019-05-20" @default.
- W2947105704 modified "2023-09-27" @default.
- W2947105704 title "Learnings from a pragmatic study to evaluate benefit of performing reflex clinical trial matching and providing clinical decision support to physicians." @default.
- W2947105704 doi "https://doi.org/10.1200/jco.2019.37.15_suppl.e18006" @default.
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