FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947109750> ?p ?o ?g. }

• W2947109750 abstract "The Drug Burden Index (DBI) quantifies exposure to medications with anticholinergic and/or sedative effects. A consensus list of DBI medications available in Ireland was recently developed for use as a DBI tool. The aim of this study was to validate this DBI tool by examining the association of DBI score with important health outcomes in Irish community-dwelling older people.This was a cohort study using data from The Irish Longitudinal Study on Ageing (TILDA) with linked pharmacy claims data. Individuals aged ≥65 years participating in TILDA and enrolled in the General Medical Services scheme were eligible for inclusion. DBI score was determined by applying the DBI tool to participants' medication dispensing data in the year prior to outcome assessment. DBI score was recoded into a categorical variable [none (0), low (> 0 and < 1), and high (≥1)]. Outcome measures included any Activities of Daily Living (ADL) impairment, any Instrumental Activities of Daily Living (IADL) impairment, any self-reported fall in the previous 12 months, any frailty criterion met (Fried Phenotype measure), quality of life (QoL) score (CASP-19 [Control Autonomy Self-realisation Pleasure] measure), and healthcare utilisation (any hospital admission and any emergency department (ED) visit) in the previous 12 months. Statistical analyses included multivariate logistic and linear regression models controlling for potential confounders.61.3% (n = 1946) of participants received at least one DBI prescription in the year before their outcome assessment. High DBI exposure (DBI score ≥ 1) vs none was significantly associated with impaired function (ADL impairment adjusted OR 1.89, 95% CI 1.25, 2.88; IADL impairment adjusted OR 2.97, 95% CI 1.91, 4.61), self-reported falls (adjusted OR 1.50, 95%CI 1.03, 2.18), frailty (adjusted OR 1.74, 95% CI 1.14, 2.67), and reduced QoL (β = - 1.84, 95%CI -3.14, - 0.54). There was no significant association between DBI exposure and healthcare utilisation.The findings validate the use of the DBI tool for predicting risk of functional impairment, falls, frailty and reduced QoL in older people in Ireland, and may be extended to other European countries. Integration of this tool into routine practice may be an appropriate step forward to improve outcomes in older people." @default.
• W2947109750 created "2019-06-07" @default.
• W2947109750 creator A5015600063 @default.
• W2947109750 creator A5023760246 @default.
• W2947109750 creator A5044469294 @default.
• W2947109750 creator A5064964943 @default.
• W2947109750 date "2019-04-29" @default.
• W2947109750 modified "2023-10-14" @default.
• W2947109750 title "Impact of drug burden index on adverse health outcomes in Irish community-dwelling older people: a cohort study" @default.
• W2947109750 cites W1525679909 @default.
• W2947109750 cites W1847168837 @default.
• W2947109750 cites W1947134347 @default.
• W2947109750 cites W1966342085 @default.
• W2947109750 cites W1967974729 @default.
• W2947109750 cites W1968911438 @default.
• W2947109750 cites W2001917448 @default.
• W2947109750 cites W2003548575 @default.
• W2947109750 cites W2008854521 @default.
• W2947109750 cites W2028771459 @default.
• W2947109750 cites W2057000152 @default.
• W2947109750 cites W2058161128 @default.
• W2947109750 cites W2074318830 @default.
• W2947109750 cites W2078432203 @default.
• W2947109750 cites W2078799882 @default.
• W2947109750 cites W2081315480 @default.
• W2947109750 cites W2095439262 @default.
• W2947109750 cites W2112778345 @default.
• W2947109750 cites W2114539601 @default.
• W2947109750 cites W2123418623 @default.
• W2947109750 cites W2125557164 @default.
• W2947109750 cites W2126292472 @default.
• W2947109750 cites W2128529067 @default.
• W2947109750 cites W2136053117 @default.
• W2947109750 cites W2146172316 @default.
• W2947109750 cites W2147965610 @default.
• W2947109750 cites W2148080316 @default.
• W2947109750 cites W2161226067 @default.
• W2947109750 cites W2164059021 @default.
• W2947109750 cites W2166871517 @default.
• W2947109750 cites W2167311298 @default.
• W2947109750 cites W2557564208 @default.
• W2947109750 cites W2746923656 @default.
• W2947109750 cites W2765826682 @default.
• W2947109750 cites W2773631971 @default.
• W2947109750 cites W2783910042 @default.
• W2947109750 cites W2840729980 @default.
• W2947109750 doi "https://doi.org/10.1186/s12877-019-1138-7" @default.
• W2947109750 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6489229" @default.
• W2947109750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31035946" @default.
• W2947109750 hasPublicationYear "2019" @default.
• W2947109750 type Work @default.
• W2947109750 sameAs 2947109750 @default.
• W2947109750 citedByCount "20" @default.
• W2947109750 countsByYear W29471097502019 @default.
• W2947109750 countsByYear W29471097502020 @default.
• W2947109750 countsByYear W29471097502021 @default.
• W2947109750 countsByYear W29471097502022 @default.
• W2947109750 countsByYear W29471097502023 @default.
• W2947109750 crossrefType "journal-article" @default.
• W2947109750 hasAuthorship W2947109750A5015600063 @default.
• W2947109750 hasAuthorship W2947109750A5023760246 @default.
• W2947109750 hasAuthorship W2947109750A5044469294 @default.
• W2947109750 hasAuthorship W2947109750A5064964943 @default.
• W2947109750 hasBestOaLocation W29471097501 @default.
• W2947109750 hasConcept C118552586 @default.
• W2947109750 hasConcept C126322002 @default.
• W2947109750 hasConcept C142724271 @default.
• W2947109750 hasConcept C159110408 @default.
• W2947109750 hasConcept C1862650 @default.
• W2947109750 hasConcept C201903717 @default.
• W2947109750 hasConcept C2426938 @default.
• W2947109750 hasConcept C2777895361 @default.
• W2947109750 hasConcept C2779951463 @default.
• W2947109750 hasConcept C2780724011 @default.
• W2947109750 hasConcept C71924100 @default.
• W2947109750 hasConcept C72563966 @default.
• W2947109750 hasConcept C74909509 @default.
• W2947109750 hasConcept C79544238 @default.
• W2947109750 hasConcept C98274493 @default.
• W2947109750 hasConceptScore W2947109750C118552586 @default.
• W2947109750 hasConceptScore W2947109750C126322002 @default.
• W2947109750 hasConceptScore W2947109750C142724271 @default.
• W2947109750 hasConceptScore W2947109750C159110408 @default.
• W2947109750 hasConceptScore W2947109750C1862650 @default.
• W2947109750 hasConceptScore W2947109750C201903717 @default.
• W2947109750 hasConceptScore W2947109750C2426938 @default.
• W2947109750 hasConceptScore W2947109750C2777895361 @default.
• W2947109750 hasConceptScore W2947109750C2779951463 @default.
• W2947109750 hasConceptScore W2947109750C2780724011 @default.
• W2947109750 hasConceptScore W2947109750C71924100 @default.
• W2947109750 hasConceptScore W2947109750C72563966 @default.
• W2947109750 hasConceptScore W2947109750C74909509 @default.
• W2947109750 hasConceptScore W2947109750C79544238 @default.
• W2947109750 hasConceptScore W2947109750C98274493 @default.
• W2947109750 hasFunder F4320312041 @default.
• W2947109750 hasIssue "1" @default.
• W2947109750 hasLocation W29471097501 @default.
• W2947109750 hasLocation W29471097502 @default.
• W2947109750 hasLocation W29471097503 @default.
• W2947109750 hasLocation W29471097504 @default.

• next