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- W2947118849 abstract "A simple and easy condensation reaction of aryl- or N-substituted isatins with Girard's reagents P and T was found to be useful in obtaining of water-soluble isatin-based quaternary ammonium compounds (QACs) bearing pyridinium or trimethylammonium moiety with high yields. Their antimicrobial activity was evaluated. Selective activity against Gram-positive bacteria (S. aureus 209p and B. cereus 8035) and yeast-like fungus Candida albicans 855–653 was shown. The influence of the substituent's nature as in the aromatic fragment as at position 1 on the activity was established. The most active are the pyridinium salts containing sterically hindered phenolic fragment at the position 1 of the heterocycle. The structures of all novel compounds were fully characterized using IR and NMR spectroscopies as well as XRD analysis." @default.
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- W2947118849 date "2019-05-27" @default.
- W2947118849 modified "2023-10-16" @default.
- W2947118849 title "Synthesis and Biological Evaluation of New Isatin‐Based QACs with High Antimicrobial Potency" @default.
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- W2947118849 doi "https://doi.org/10.1002/slct.201901708" @default.
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