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• W2947160840 endingPage "104289" @default.
• W2947160840 startingPage "104289" @default.
• W2947160840 abstract "Tuberculosis (TB) is currently a clinical and public health problem. There is a concern about the emergence and development of multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) species. Additionally, the lack of effective vaccines is another limitation to control the related infections. To overcome these problems various approaches have been pursued such as finding novel drug candidates with a new mechanism of action or repurposing conventional antibiotics. However, these strategies are still far from clinical application. Hence, the use of adjunctive therapy has been suggested for TB. In this paper, we review non-antibiotic adjunctive treatment options for TB. Natural products, vitamins, micronutrients, and trace elementals, as well as non-antibiotic drugs, are examples of agents which have been used as adjunctive therapies. The use of these adjunctive therapies has been shown to improve disease outcomes and reduce the adverse effects of antibiotic drugs. Employing these agents, either alone or in combination with antibiotics, might be considered as a promising approach to control TB infections and achieve better clinical outcomes. However, supportive evidence from randomized controlled trials is still scant and merits further investigations." @default.
• W2947160840 created "2019-06-07" @default.
• W2947160840 creator A5019585280 @default.
• W2947160840 creator A5020124153 @default.
• W2947160840 creator A5020639473 @default.
• W2947160840 creator A5042169973 @default.
• W2947160840 creator A5050732377 @default.
• W2947160840 date "2019-08-01" @default.
• W2947160840 modified "2023-09-23" @default.
• W2947160840 title "Non-antibiotic adjunctive therapy: A promising approach to fight tuberculosis" @default.
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