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- W2947163054 abstract "Significance G protein-coupled receptors (GPCRs) regulate a wide variety of important cellular processes and are targeted by a large fraction of approved drugs. GPCRs signal by activating heterotrimeric G proteins and must couple to a select subset of G proteins to produce appropriate intracellular responses. It is not known how GPCRs select G proteins, but it is generally accepted that the Gα subunit C terminus is the primary G protein determinant of coupling selectivity. We systematically studied coupling of GPCRs to four families of G proteins and chimeras with C terminal regions that were exchanged between families. We uncovered rules for coupling selectivity and found that different GPCRs can recognize different features of the same G protein for selective coupling." @default.
- W2947163054 created "2019-06-07" @default.
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- W2947163054 date "2019-05-29" @default.
- W2947163054 modified "2023-10-14" @default.
- W2947163054 title "Variable G protein determinants of GPCR coupling selectivity" @default.
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- W2947163054 doi "https://doi.org/10.1073/pnas.1905993116" @default.
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