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- W2947172488 abstract "Since the original phase III non-inferiority studies comparing direct oral anticoagulants (DOA) to warfarin, numerous other trials have tried to answer the questions regarding the efficacy and safety of use of DOAs in elderly patients. These studies are additional sub-group trials based on the original studies, or post-marketing pharmacovigilance studies using large-scale medical and economic data. By definition, numerous biases may lead to a distortion in the results in such studies, and they should be interpreted with caution. To date, there have been no controlled randomised studies that have compared DOAs to warfarin in patients aged 80 years or above, and in particular in patients who are frail. In practice, for frail patients, there is no consensus when it comes to selecting which anticoagulant to prescribe in cases of atrial fibrillation (AF) or venous thromboembolism (VTE). Regarding the preferred choice of DOAs for elderly patients, the lack of direct comparative studies available to date makes selecting one difficult. Nevertheless, available data, both on a pharmacological level and from additional studies appears to show that dabigatran offers a less favourable risk/benefit profile than other DOAs. However, the promising results for idarucizumab, an antidote for dabigatran, could potentially improve this ratio in the future." @default.
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- W2947172488 date "2015-01-01" @default.
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- W2947172488 title "Les anticoagulants oraux directs en 2015 chez le patient âgé : focus chez le sujet fragile Direct Oral Anticoagulants in 2015 for the Elderly: a Focus on Frail Patients" @default.
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