Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947180812> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2947180812 abstract "e14280 Background: Biomarkers would enrich patients(pts) with responsiveness to both targeted treatments and immunotherapy which have become a priority. However, molecular heterogeneous in actionable gene alterations and mutational loads need to be explored. In this study, based on a real world setting, Cancer Gene Panel (CGP） analysis was performed in a series samples of Chinese pts with advanced solid tumors, to delineate the landscape of actionable mutations and tumor mutational burden (TMB). Methods: 176 advanced pts were enrolled encompassing 19 common tumor types. All tissue samples were analyzed using next-generation sequencing with Acornmed panel including 808 genes. Results: The frequencies of genetic alterations among the most common driver genes were comparable to those reported by MSK-IMPACT (2018) ( TP53: 51.7% vs 44.8%; APC: 9.7% vs 9.8%; EGFR: 12.5% vs 7.7%; KRAS: 16.5% vs 13.6%; PIK3CA: 4.6% vs 12.0%; VHL: 4.0% vs 6.7%). 58.3% of pts with refractory solid tumors had at least one actionable mutation. Among those pts, 16.7% of them including CDK4, CDK6 or CDKN2A/B could benefit from palbociclib, and 32.1% of them including mTOR, PIK3CA, PTEN or STK11 could benefit from everolimus, and 61.9% of them including BRCA2, ARID1A, MSH1/2/6 or ATM could benefit from olaparib. Across all the specimens, the top 20% of TMB was 17.23 mutations/Mb, with a range of 0-48 mutations/Mb. The top 20% of TMB for each tumor type was 21.67(Bladder cancer), 17.23(Lung cancer), 16.45(Colorectal cancer), 11.04 (Renal cell cancer), 16.25 (Prostate cancer) , 19.70 (Hepatobiliary cancer), 14.78 (Esophagogastric cancer), 7.80 (Pancreatic cancer), 25.31 (undefined tumor) mutations/Mb respectively. Conclusions: This study indicates that most of pts with advanced refractory solid tumors have at least one actionable mutation, and matched therapies may confer clinical benefit. TMB fluctuated wildly across different cancer types, illustrating the unequal objective response rate of immunotherapy across various cancer type. Furthermore, CGP analysis in advanced pan-cancer pts can provide opportunities for targeted therapies and immunotherapy, especially in those with refractory cancer." @default.
- W2947180812 created "2019-06-07" @default.
- W2947180812 creator A5016136940 @default.
- W2947180812 creator A5020284608 @default.
- W2947180812 creator A5041140966 @default.
- W2947180812 creator A5052532604 @default.
- W2947180812 creator A5066611713 @default.
- W2947180812 creator A5079351264 @default.
- W2947180812 creator A5087404367 @default.
- W2947180812 date "2019-05-20" @default.
- W2947180812 modified "2023-09-27" @default.
- W2947180812 title "Biomarkers of Chinese advanced cancer patients based on real-world data: Actionable genomic alterations and tumor mutational burden." @default.
- W2947180812 doi "https://doi.org/10.1200/jco.2019.37.15_suppl.e14280" @default.
- W2947180812 hasPublicationYear "2019" @default.
- W2947180812 type Work @default.
- W2947180812 sameAs 2947180812 @default.
- W2947180812 citedByCount "0" @default.
- W2947180812 crossrefType "journal-article" @default.
- W2947180812 hasAuthorship W2947180812A5016136940 @default.
- W2947180812 hasAuthorship W2947180812A5020284608 @default.
- W2947180812 hasAuthorship W2947180812A5041140966 @default.
- W2947180812 hasAuthorship W2947180812A5052532604 @default.
- W2947180812 hasAuthorship W2947180812A5066611713 @default.
- W2947180812 hasAuthorship W2947180812A5079351264 @default.
- W2947180812 hasAuthorship W2947180812A5087404367 @default.
- W2947180812 hasConcept C121608353 @default.
- W2947180812 hasConcept C126322002 @default.
- W2947180812 hasConcept C143998085 @default.
- W2947180812 hasConcept C2522767166 @default.
- W2947180812 hasConcept C3020493868 @default.
- W2947180812 hasConcept C3020497934 @default.
- W2947180812 hasConcept C41008148 @default.
- W2947180812 hasConcept C502942594 @default.
- W2947180812 hasConcept C60644358 @default.
- W2947180812 hasConcept C71924100 @default.
- W2947180812 hasConcept C86803240 @default.
- W2947180812 hasConceptScore W2947180812C121608353 @default.
- W2947180812 hasConceptScore W2947180812C126322002 @default.
- W2947180812 hasConceptScore W2947180812C143998085 @default.
- W2947180812 hasConceptScore W2947180812C2522767166 @default.
- W2947180812 hasConceptScore W2947180812C3020493868 @default.
- W2947180812 hasConceptScore W2947180812C3020497934 @default.
- W2947180812 hasConceptScore W2947180812C41008148 @default.
- W2947180812 hasConceptScore W2947180812C502942594 @default.
- W2947180812 hasConceptScore W2947180812C60644358 @default.
- W2947180812 hasConceptScore W2947180812C71924100 @default.
- W2947180812 hasConceptScore W2947180812C86803240 @default.
- W2947180812 hasLocation W29471808121 @default.
- W2947180812 hasOpenAccess W2947180812 @default.
- W2947180812 hasPrimaryLocation W29471808121 @default.
- W2947180812 hasRelatedWork W1506621876 @default.
- W2947180812 hasRelatedWork W1972922858 @default.
- W2947180812 hasRelatedWork W2053752413 @default.
- W2947180812 hasRelatedWork W2064919087 @default.
- W2947180812 hasRelatedWork W2167179525 @default.
- W2947180812 hasRelatedWork W2186430717 @default.
- W2947180812 hasRelatedWork W2190879643 @default.
- W2947180812 hasRelatedWork W2267629394 @default.
- W2947180812 hasRelatedWork W2624353981 @default.
- W2947180812 hasRelatedWork W2745518265 @default.
- W2947180812 hasRelatedWork W2800192344 @default.
- W2947180812 hasRelatedWork W2888864474 @default.
- W2947180812 hasRelatedWork W2909164545 @default.
- W2947180812 hasRelatedWork W2914818120 @default.
- W2947180812 hasRelatedWork W2966796460 @default.
- W2947180812 hasRelatedWork W3003621599 @default.
- W2947180812 hasRelatedWork W3006580035 @default.
- W2947180812 hasRelatedWork W3044002837 @default.
- W2947180812 hasRelatedWork W3196601876 @default.
- W2947180812 hasRelatedWork W782266251 @default.
- W2947180812 isParatext "false" @default.
- W2947180812 isRetracted "false" @default.
- W2947180812 magId "2947180812" @default.
- W2947180812 workType "article" @default.