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- W2947204028 endingPage "703" @default.
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- W2947204028 abstract "Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support the existence of a de novo pathway for acetate production derived from pyruvate, the end product of glycolysis. This mechanism of pyruvate-derived acetate generation could have far-reaching implications for the regulation of central carbon metabolism. In this Opinion, we discuss our current understanding of acetate metabolism in the context of cell-autonomous metabolic regulation, cell-cell interactions, and systemic physiology. Applications relevant to health and disease, particularly cancer, are emphasized." @default.
- W2947204028 created "2019-06-07" @default.
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- W2947204028 date "2019-09-01" @default.
- W2947204028 modified "2023-10-17" @default.
- W2947204028 title "Acetate Metabolism in Physiology, Cancer, and Beyond" @default.
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- W2947204028 doi "https://doi.org/10.1016/j.tcb.2019.05.005" @default.
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