Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947219350> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2947219350 endingPage "212" @default.
- W2947219350 startingPage "207" @default.
- W2947219350 abstract "Background: Currently there is no medical treatment for X-linked retinoschisis (XLRS). In many retinal dystrophies, carbonic anhydrase inhibitors (CAIs) are effectively used to reduce cystoid macular edema. Prospective studies investigating the effect of CAIs in patients with XLRS are needed for the evaluation of their efficacy in this disease. The purpose of our work is to investigate the effects on macular morphology and function of oral CAIs used for the treatment of foveal lesions in patients with XLRS. Methods: Nineteen patients with a clinical diagnosis of XLRS were enrolled and prescribed oral CAIs for six months. We evaluated the therapeutic effect of CAIs with: best-corrected visual acuity (BCVA), spectral-domain optical coherence tomography, microperimetry (MP) and multifocal electroretinography (mfERG). Results: We observed a significant improvement of BCVA (p-value = 0.013), central retinal thickness (p-value = 0.004) and macular sensitivity (p-value<0.001). Moreover, in regards to mfERG responses, an increase of P1 wave amplitude was observed in three of the six rings. Conclusions: Our data supports the efficacy of oral CAIs for the treatment of macular cyst-like lesions in XLRS patients. The recovery of a normal retinal anatomy by means of oral CAIs could be useful to create the optimal circumstances for gene therapy. The increase in macular sensitivity and in P1 wave amplitude confirmed that MP and mfERG provide with an unbiased and more sensitive understanding of how macular function may respond to the use of CAIs. Therefore, we recommend the use of MP and mfERG to assess the effect of therapy in XLRS." @default.
- W2947219350 created "2019-06-07" @default.
- W2947219350 creator A5008975956 @default.
- W2947219350 creator A5017458885 @default.
- W2947219350 creator A5028681763 @default.
- W2947219350 creator A5049773865 @default.
- W2947219350 creator A5050068391 @default.
- W2947219350 creator A5063910500 @default.
- W2947219350 creator A5069989966 @default.
- W2947219350 creator A5071595622 @default.
- W2947219350 date "2019-05-04" @default.
- W2947219350 modified "2023-10-16" @default.
- W2947219350 title "Carbonic anhydrase inhibitors in patients with X-linked retinoschisis: effects on macular morphology and function" @default.
- W2947219350 cites W1939826772 @default.
- W2947219350 cites W1974019768 @default.
- W2947219350 cites W1976026899 @default.
- W2947219350 cites W1976566530 @default.
- W2947219350 cites W1987822684 @default.
- W2947219350 cites W1999451522 @default.
- W2947219350 cites W2003603723 @default.
- W2947219350 cites W2030877659 @default.
- W2947219350 cites W2035850269 @default.
- W2947219350 cites W2051885327 @default.
- W2947219350 cites W2061105073 @default.
- W2947219350 cites W2096257125 @default.
- W2947219350 cites W2097852384 @default.
- W2947219350 cites W2109335923 @default.
- W2947219350 cites W2116685548 @default.
- W2947219350 cites W2501414412 @default.
- W2947219350 cites W2527736065 @default.
- W2947219350 cites W2555780033 @default.
- W2947219350 cites W2556261073 @default.
- W2947219350 cites W2556711442 @default.
- W2947219350 cites W2802611681 @default.
- W2947219350 doi "https://doi.org/10.1080/13816810.2019.1616303" @default.
- W2947219350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31149861" @default.
- W2947219350 hasPublicationYear "2019" @default.
- W2947219350 type Work @default.
- W2947219350 sameAs 2947219350 @default.
- W2947219350 citedByCount "18" @default.
- W2947219350 countsByYear W29472193502019 @default.
- W2947219350 countsByYear W29472193502021 @default.
- W2947219350 countsByYear W29472193502022 @default.
- W2947219350 countsByYear W29472193502023 @default.
- W2947219350 crossrefType "journal-article" @default.
- W2947219350 hasAuthorship W2947219350A5008975956 @default.
- W2947219350 hasAuthorship W2947219350A5017458885 @default.
- W2947219350 hasAuthorship W2947219350A5028681763 @default.
- W2947219350 hasAuthorship W2947219350A5049773865 @default.
- W2947219350 hasAuthorship W2947219350A5050068391 @default.
- W2947219350 hasAuthorship W2947219350A5063910500 @default.
- W2947219350 hasAuthorship W2947219350A5069989966 @default.
- W2947219350 hasAuthorship W2947219350A5071595622 @default.
- W2947219350 hasConcept C118487528 @default.
- W2947219350 hasConcept C126322002 @default.
- W2947219350 hasConcept C2777405951 @default.
- W2947219350 hasConcept C2778257484 @default.
- W2947219350 hasConcept C2779100554 @default.
- W2947219350 hasConcept C2779113765 @default.
- W2947219350 hasConcept C2779594218 @default.
- W2947219350 hasConcept C2780347916 @default.
- W2947219350 hasConcept C2780428090 @default.
- W2947219350 hasConcept C2780827179 @default.
- W2947219350 hasConcept C71924100 @default.
- W2947219350 hasConceptScore W2947219350C118487528 @default.
- W2947219350 hasConceptScore W2947219350C126322002 @default.
- W2947219350 hasConceptScore W2947219350C2777405951 @default.
- W2947219350 hasConceptScore W2947219350C2778257484 @default.
- W2947219350 hasConceptScore W2947219350C2779100554 @default.
- W2947219350 hasConceptScore W2947219350C2779113765 @default.
- W2947219350 hasConceptScore W2947219350C2779594218 @default.
- W2947219350 hasConceptScore W2947219350C2780347916 @default.
- W2947219350 hasConceptScore W2947219350C2780428090 @default.
- W2947219350 hasConceptScore W2947219350C2780827179 @default.
- W2947219350 hasConceptScore W2947219350C71924100 @default.
- W2947219350 hasFunder F4320321179 @default.
- W2947219350 hasIssue "3" @default.
- W2947219350 hasLocation W29472193501 @default.
- W2947219350 hasLocation W29472193502 @default.
- W2947219350 hasOpenAccess W2947219350 @default.
- W2947219350 hasPrimaryLocation W29472193501 @default.
- W2947219350 hasRelatedWork W1996187756 @default.
- W2947219350 hasRelatedWork W2017060307 @default.
- W2947219350 hasRelatedWork W2036214396 @default.
- W2947219350 hasRelatedWork W2057093974 @default.
- W2947219350 hasRelatedWork W2065273882 @default.
- W2947219350 hasRelatedWork W2073975355 @default.
- W2947219350 hasRelatedWork W22453887 @default.
- W2947219350 hasRelatedWork W2323292712 @default.
- W2947219350 hasRelatedWork W2947219350 @default.
- W2947219350 hasRelatedWork W3029608582 @default.
- W2947219350 hasVolume "40" @default.
- W2947219350 isParatext "false" @default.
- W2947219350 isRetracted "false" @default.
- W2947219350 magId "2947219350" @default.
- W2947219350 workType "article" @default.