Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947242568> ?p ?o ?g. }
- W2947242568 abstract "Abstract Staphylococcus aureus causes serious medical problems in human and animals. Here we show that S. aureus can compromise host genomic integrity as indicated by bacteria-induced histone H2AX phosphorylation, a marker of DNA double strand breaks (DSBs), in human cervix cancer HeLa and osteoblast-like MG-63 cells. This DNA damage is mediated by alpha phenol-soluble modulins (PSMα 1–4 ), while a specific class of lipoproteins (Lpls), encoded on a pathogenicity island in S. aureus , dampens the H2AX phosphorylation thus counteracting the DNA damage. This DNA damage is mediated by reactive oxygen species (ROS), which promotes oxidation of guanine forming 7,8-dihydro-8-oxoguanine (8-oxoG). DNA damage is followed by the induction of DNA repair that involves the ATM kinase-signaling pathway. An examination of S. aureus strains, isolated from the same patient during acute initial and recurrent bone and joint infections (BJI), showed that recurrent strains produce lower amounts of Lpls, induce stronger DNA-damage and prompt the G2/M transition delay to a greater extent that suggest an involvement of these mechanisms in adaptive processes of bacteria during chronicization. Our findings redefine our understanding of mechanisms of S. aureus -host interaction and suggest that the balance between the levels of PSMα and Lpls expression impacts the persistence of the infection." @default.
- W2947242568 created "2019-06-07" @default.
- W2947242568 creator A5000255194 @default.
- W2947242568 creator A5002480359 @default.
- W2947242568 creator A5004344115 @default.
- W2947242568 creator A5014079362 @default.
- W2947242568 creator A5056173398 @default.
- W2947242568 creator A5061903214 @default.
- W2947242568 creator A5062289034 @default.
- W2947242568 creator A5065085414 @default.
- W2947242568 creator A5065597646 @default.
- W2947242568 creator A5066035786 @default.
- W2947242568 creator A5068204674 @default.
- W2947242568 creator A5069009054 @default.
- W2947242568 creator A5071849709 @default.
- W2947242568 creator A5081930265 @default.
- W2947242568 creator A5086469770 @default.
- W2947242568 creator A5088074378 @default.
- W2947242568 date "2019-05-22" @default.
- W2947242568 modified "2023-10-10" @default.
- W2947242568 title "Staphylococcus aureus induces DNA damage in host cell" @default.
- W2947242568 cites W1479712573 @default.
- W2947242568 cites W1596071457 @default.
- W2947242568 cites W1617191665 @default.
- W2947242568 cites W1719883123 @default.
- W2947242568 cites W1752089945 @default.
- W2947242568 cites W1766640855 @default.
- W2947242568 cites W1850326922 @default.
- W2947242568 cites W1852828105 @default.
- W2947242568 cites W1969166145 @default.
- W2947242568 cites W1971280435 @default.
- W2947242568 cites W1975789761 @default.
- W2947242568 cites W1985775217 @default.
- W2947242568 cites W1990967318 @default.
- W2947242568 cites W1991882828 @default.
- W2947242568 cites W1994810974 @default.
- W2947242568 cites W2003484929 @default.
- W2947242568 cites W2036995295 @default.
- W2947242568 cites W2037541009 @default.
- W2947242568 cites W2042499074 @default.
- W2947242568 cites W2042736368 @default.
- W2947242568 cites W2067427915 @default.
- W2947242568 cites W2070780407 @default.
- W2947242568 cites W2070968982 @default.
- W2947242568 cites W2074018558 @default.
- W2947242568 cites W2075479850 @default.
- W2947242568 cites W2077436902 @default.
- W2947242568 cites W2077496230 @default.
- W2947242568 cites W2081183044 @default.
- W2947242568 cites W2083678092 @default.
- W2947242568 cites W2085525271 @default.
- W2947242568 cites W2087290238 @default.
- W2947242568 cites W2088960594 @default.
- W2947242568 cites W2094009347 @default.
- W2947242568 cites W2102706796 @default.
- W2947242568 cites W2105614444 @default.
- W2947242568 cites W2108931268 @default.
- W2947242568 cites W2111541721 @default.
- W2947242568 cites W2113363693 @default.
- W2947242568 cites W2124528309 @default.
- W2947242568 cites W2124908338 @default.
- W2947242568 cites W2127416800 @default.
- W2947242568 cites W2129637612 @default.
- W2947242568 cites W2133636760 @default.
- W2947242568 cites W2133815101 @default.
- W2947242568 cites W2139175224 @default.
- W2947242568 cites W2139863514 @default.
- W2947242568 cites W2145292900 @default.
- W2947242568 cites W2146998614 @default.
- W2947242568 cites W2151722492 @default.
- W2947242568 cites W2162888767 @default.
- W2947242568 cites W2169956642 @default.
- W2947242568 cites W2181985494 @default.
- W2947242568 cites W2283757273 @default.
- W2947242568 cites W2313131808 @default.
- W2947242568 cites W2314649741 @default.
- W2947242568 cites W2507122970 @default.
- W2947242568 cites W2507916945 @default.
- W2947242568 cites W2519601881 @default.
- W2947242568 cites W2529418795 @default.
- W2947242568 cites W2561986126 @default.
- W2947242568 cites W2590864904 @default.
- W2947242568 cites W2620236845 @default.
- W2947242568 cites W2741409856 @default.
- W2947242568 cites W2754895401 @default.
- W2947242568 cites W2761297154 @default.
- W2947242568 cites W2772979724 @default.
- W2947242568 cites W2773100884 @default.
- W2947242568 doi "https://doi.org/10.1038/s41598-019-44213-3" @default.
- W2947242568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6531466" @default.
- W2947242568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31118484" @default.
- W2947242568 hasPublicationYear "2019" @default.
- W2947242568 type Work @default.
- W2947242568 sameAs 2947242568 @default.
- W2947242568 citedByCount "23" @default.
- W2947242568 countsByYear W29472425682020 @default.
- W2947242568 countsByYear W29472425682021 @default.
- W2947242568 countsByYear W29472425682022 @default.
- W2947242568 countsByYear W29472425682023 @default.
- W2947242568 crossrefType "journal-article" @default.