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• W2947254930 abstract "Percutaneous coronary intervention is commonly employed for revascularization. These strategies, however, injure the arterial wall initiating a cascade of inflammatory responses that culminates in restenosis. In our research work, we proposed to use a platelet mimicking fluorescent nano-scaffold system that can cloak an injured artery site from inflammatory cells, capture the endothelial progenitor cells using specialized targeting agents, and promote in situ endothelial regeneration. We used photo-luminescent polylactone (BPLP) copolymers such as BPLP-co-poly(L-lactide) (BPLP-PLLA) and BPLP-co-poly(lactic-co-glycolic) acid (BPLP-PLGA50:50 and BPLP-PLGA75:25) to prepare nanoscaffolds; their intrinsic fluorescent properties help us localize and monitor the scaffold’s degradation in vivo as endothelial regeneration ensues. Our initial studies were focused on optimizing a suitable polymer to be used to make a novel nano-scaffold system. We fabricated ~200 nm sized BSA-loaded BPLP-polylactone based nanoparticles by standard double emulsion method. BPLP-PLGA based particles released BSA within 14 days, however, BPLP-PLLA showed slow and continued release for 28 days. BPLP-PLGA degraded completely within 4 weeks of study, whereas BPLP-PLLA degraded only 20% during the same time. The cyto-compatibility study showed that the BPLP-PLGA50:50, especially at high concentrations (> 1000μg/ml), is significantly toxic to the human umbilical vein endothelial cells; however, no such toxicity was observed for BPLP-PLGA75:25 and BPLP-PLLA. Hemo-compatibility of the particles demonstrated that they didn’t cause any significant lysis of red blood cells, and neither affected blood clotting kinetics compared to that of the control. Furthermore, we observed a minimal number of platelet attachment and activation on BPLP-PLGA materials compared to that of the glass surface. Based on these initial results we selected BPLP-PLGA 75:25 to fabricate nanoscaffolds. Currently, we are optimizing the effective particle size to enhance their margination towards the arterial wall and other factors, including specialized capturing agents to capture EPC, and growth factor cocktail to improve EPC homing and differentiation at the injured site." @default.
• W2947254930 created "2019-06-07" @default.
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• W2947254930 date "2017-05-01" @default.
• W2947254930 modified "2023-09-25" @default.
• W2947254930 title "Abstract 355: Photoluminescent Polylactones Based Nanoscaffolds for Enhancing Reendothelialization" @default.
• W2947254930 doi "https://doi.org/10.1161/atvb.37.suppl_1.355" @default.
• W2947254930 hasPublicationYear "2017" @default.
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