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• W2947273670 abstract "The imbalance between MMPs and TIMPs is associated with the HIV dissemination tissue damage pathology neurodegenerative disorders, including HAND. Genetic variations in the TIMP gene may modulate the neurocognitive disorder in HIV patients. Hence, we evaluated the genetic variants of TIMP -2 ( - 418G/C, 303G/A) gene with the risk of HAND. Genotyping of TIMP -2 polymorphism was performed in 50 patients with HAND, 100 no HAND, and 154 healthy controls by PCR-RFLP. TIMP-2 -418GC and 303AA genotypes represented a predominant risk for HAND severity (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>1.55</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.30</mml:mn></mml:math>;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>4.58</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.24</mml:mn></mml:math>). The variant -418CC genotype, -418A allele, had exhibited a significant risk for the acquisition of HAND (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>12.55</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.026</mml:mn></mml:math>;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>2.66</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.004</mml:mn></mml:math>). TIMP-2 303GA, 303AA genotype, and 303A allele evinced a higher risk for HAND severity (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>1.82</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.14</mml:mn></mml:math>;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>1.70</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.63</mml:mn></mml:math>; and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>1.68</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M14><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.12</mml:mn></mml:math>). In HIV patients, TIMP - 2 -418CC genotype and -418C allele significantly occurred in comparison to healthy controls (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M15><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>10.10</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M16><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.006</mml:mn></mml:math>;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M17><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>2.02</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M18><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.009</mml:mn></mml:math>). In the intermediate and early HIV disease stage, TIMP-2 -418CC genotype was significantly increased compared with healthy controls (11.1% vs. 1.3%,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M19><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>14.63</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M20><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.01</mml:mn></mml:math>; 16.9% vs. 1.3%,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M21><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>14.51</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M22><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.002</mml:mn></mml:math>). In patients with HAND among tobacco and alcohol users, TIMP-2 -418CC genotype displayed a risk for HAND severity (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M23><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>3.96</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M24><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.26</mml:mn></mml:math>;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M25><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>4.83</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M26><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.19</mml:mn></mml:math>). On multivariate logistic regression, TIMP-2 303AA genotype, advanced stage, and gender had a risk for HAND severity (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M27><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>28.98</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M28><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.02</mml:mn></mml:math>;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M29><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>2.35</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M30><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.070</mml:mn></mml:math>; and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M31><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>2.36</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M32><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.04</mml:mn></mml:math>). In conclusion, TIMP-2 -418G/C polymorphism independently, along with alcohol and tobacco, may have an impact on the acquisition of HAND and its severity. TIMP-2 303G/A polymorphism bare a risk for HAND severity." @default.
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• W2947273670 date "2019-05-28" @default.
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• W2947273670 title "Tissue Inhibitor of Metalloproteinase-2 Polymorphisms and Risk for HIV-Associated Neurocognitive Disorder" @default.
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