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- W2947274328 abstract "Cefazolin sodium was synthesized using 7-amino cephalosporanic acid (7-ACCA) and H-tertrazole acetic acid (TAA) by acylation reaction in methylene chloride as a solvent and pivaloyl chloride as a catalyst. Various parameters involving synthesis such as duration, temperature, pH, catalyst (acidic and basic), coupling and activating agents were optimized. The product yield was more than 100% with 98% purity as per BP/ USP specifications. The material kept at 70C and 75% of relative humidity for 72 h showed a slight change in general appearance from almost white to off white with 3-4% loss of weight due to removal of water, while pH of the material before and after the tests remained almost the same. The material complied well with pharmacopoeia specification. The described synthesis is found to be simple, efficient and economical and may be used by pharmaceutical raw material industry" @default.
- W2947274328 created "2019-06-07" @default.
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- W2947274328 date "2018-05-27" @default.
- W2947274328 modified "2023-09-27" @default.
- W2947274328 title "IMPROVED AND ECONOMICAL SYNTHESIS OF CEFAZOLIN SODIUM" @default.
- W2947274328 hasPublicationYear "2018" @default.
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