Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947303564> ?p ?o ?g. }
- W2947303564 endingPage "91" @default.
- W2947303564 startingPage "76" @default.
- W2947303564 abstract "Epsilon toxin (ETX) is the major virulence determinant of C. perfringens type B or type D strains, causing diseases in animals, besides being a listed biological and toxin warfare (BTW) agent. Keeping in mind the high lethality and the rapid onset of clinical manifestations, early diagnosis of epsilon toxin exposure is of paramount importance for implementation of appropriate medical countermeasures. Using a 2DE-MS approach, the present study is the first comprehensive proteomic elucidation of ETX-induced protein markers in the mouse model, providing putative targets for early diagnosis of ETX exposure. A total of 52 unique proteins showing ETX-induced modulations were identified in plasma and urine samples. Fibrinogen, apolipoprotein, serum amyloid protein, plasminogen, serum albumin, glutathione peroxidase, transferrin, major urinary protein 2, haptoglobin, transthyretin, and vitamin D-binding protein were among the proteins observed in more than one dataset with altered abundance after the ETX-intoxication. The predicted localization, function, and interaction of the ETX-modulated proteins in the plasma and urine indicated involvement of multiple pathways; extracellular proteins, followed by macromolecular complexes associated with blood coagulation and plasminogen activating cascade, being the most prominent among others. The putative markers elucidated here warrants further validation and can be of immense value for the early diagnosis of ETX exposure." @default.
- W2947303564 created "2019-06-07" @default.
- W2947303564 creator A5044898855 @default.
- W2947303564 creator A5058648789 @default.
- W2947303564 creator A5058912819 @default.
- W2947303564 creator A5062448261 @default.
- W2947303564 creator A5076653096 @default.
- W2947303564 creator A5087120736 @default.
- W2947303564 date "2019-10-01" @default.
- W2947303564 modified "2023-10-18" @default.
- W2947303564 title "Elucidation of protein biomarkers in plasma and urine for epsilon toxin exposure in mouse model" @default.
- W2947303564 cites W1561024000 @default.
- W2947303564 cites W1682345769 @default.
- W2947303564 cites W1847021296 @default.
- W2947303564 cites W1968449024 @default.
- W2947303564 cites W1972731882 @default.
- W2947303564 cites W1977184198 @default.
- W2947303564 cites W1979453310 @default.
- W2947303564 cites W1982479634 @default.
- W2947303564 cites W1984561439 @default.
- W2947303564 cites W1985947600 @default.
- W2947303564 cites W1986868774 @default.
- W2947303564 cites W2003785030 @default.
- W2947303564 cites W2005948802 @default.
- W2947303564 cites W2010168508 @default.
- W2947303564 cites W2010997088 @default.
- W2947303564 cites W2011576588 @default.
- W2947303564 cites W2014848125 @default.
- W2947303564 cites W2022807001 @default.
- W2947303564 cites W2032896244 @default.
- W2947303564 cites W2036070425 @default.
- W2947303564 cites W2037120131 @default.
- W2947303564 cites W2037804586 @default.
- W2947303564 cites W2038431896 @default.
- W2947303564 cites W2045704125 @default.
- W2947303564 cites W2046777097 @default.
- W2947303564 cites W2052528121 @default.
- W2947303564 cites W2055225004 @default.
- W2947303564 cites W2057545775 @default.
- W2947303564 cites W2059872910 @default.
- W2947303564 cites W2062051257 @default.
- W2947303564 cites W2066511101 @default.
- W2947303564 cites W2068082564 @default.
- W2947303564 cites W2072542212 @default.
- W2947303564 cites W2074836708 @default.
- W2947303564 cites W2078733235 @default.
- W2947303564 cites W2084348622 @default.
- W2947303564 cites W2102792821 @default.
- W2947303564 cites W2103496411 @default.
- W2947303564 cites W2104589433 @default.
- W2947303564 cites W2109257248 @default.
- W2947303564 cites W2110078066 @default.
- W2947303564 cites W2111883347 @default.
- W2947303564 cites W2112618002 @default.
- W2947303564 cites W2113131573 @default.
- W2947303564 cites W2120585781 @default.
- W2947303564 cites W2125488203 @default.
- W2947303564 cites W2146733021 @default.
- W2947303564 cites W2149741097 @default.
- W2947303564 cites W2153446989 @default.
- W2947303564 cites W2169263889 @default.
- W2947303564 cites W2171492466 @default.
- W2947303564 cites W2171947762 @default.
- W2947303564 cites W2172116519 @default.
- W2947303564 cites W2199111714 @default.
- W2947303564 cites W2200837721 @default.
- W2947303564 cites W2312396728 @default.
- W2947303564 cites W2800937934 @default.
- W2947303564 cites W2803795540 @default.
- W2947303564 cites W2898868241 @default.
- W2947303564 cites W4231135626 @default.
- W2947303564 doi "https://doi.org/10.1016/j.anaerobe.2019.05.010" @default.
- W2947303564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31145997" @default.
- W2947303564 hasPublicationYear "2019" @default.
- W2947303564 type Work @default.
- W2947303564 sameAs 2947303564 @default.
- W2947303564 citedByCount "2" @default.
- W2947303564 countsByYear W29473035642020 @default.
- W2947303564 countsByYear W29473035642023 @default.
- W2947303564 crossrefType "journal-article" @default.
- W2947303564 hasAuthorship W2947303564A5044898855 @default.
- W2947303564 hasAuthorship W2947303564A5058648789 @default.
- W2947303564 hasAuthorship W2947303564A5058912819 @default.
- W2947303564 hasAuthorship W2947303564A5062448261 @default.
- W2947303564 hasAuthorship W2947303564A5076653096 @default.
- W2947303564 hasAuthorship W2947303564A5087120736 @default.
- W2947303564 hasConcept C121157162 @default.
- W2947303564 hasConcept C134018914 @default.
- W2947303564 hasConcept C146543888 @default.
- W2947303564 hasConcept C185592680 @default.
- W2947303564 hasConcept C203014093 @default.
- W2947303564 hasConcept C206396517 @default.
- W2947303564 hasConcept C22814914 @default.
- W2947303564 hasConcept C2776125364 @default.
- W2947303564 hasConcept C2777367657 @default.
- W2947303564 hasConcept C2779036427 @default.
- W2947303564 hasConcept C55493867 @default.
- W2947303564 hasConcept C86803240 @default.