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- W2947351976 endingPage "70" @default.
- W2947351976 startingPage "63" @default.
- W2947351976 abstract "Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Despite recent advances in the molecular genetics of CRC, poor treatment outcomes highlight the need for a better understanding of the underlying mechanisms accounting for tumor initiation and progression. Recently, deregulation of cellular metabolism has emerged as a key hallmark of cancer. Reprogramming of core cellular metabolic pathways by cancer cells provides energy, anaplerotic precursors and reducing equivalents required to support tumor growth. Here, we review key findings implicating cancer metabolism as a major contributor of tumor initiation, growth and metastatic dissemination in CRC. We summarize the metabolic pathways governing stem cell fate in the intestine, the metabolic adaptations of proliferating colon cancer cells and their crosstalk with oncogenic signaling, and how they fulfill the energetic demands imposed by the metastatic cascade. Lastly, we discuss how some of these metabolic pathways could represent new vulnerabilities of CRC cells with the potential to be targeted." @default.
- W2947351976 created "2019-06-07" @default.
- W2947351976 creator A5018861471 @default.
- W2947351976 creator A5053596264 @default.
- W2947351976 date "2020-02-01" @default.
- W2947351976 modified "2023-10-11" @default.
- W2947351976 title "Metabolic pathways regulating colorectal cancer initiation and progression" @default.
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