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- W2947352613 abstract "Cellular inhibitor of apoptosis proteins cIAP1 and cIAP2 ubiquitinate nuclear factor κB (NF-κB)-inducing kinase (NIK) to suppress non-canonical NF-κB signaling and substrates such as receptor interacting protein kinase 1 (RIPK1) to promote cell survival. We investigate how these functions contribute to homeostasis by eliminating cIap2 from adult cIap1-deficient mice. cIAP1 and cIAP2 (cIAP1/2) deficiency causes rapid weight loss and inflammation, with aberrant cell death, indicated by cleaved caspases-3 and -8, prevalent in intestine and liver. Deletion of Casp8 and Ripk3 prevents this aberrant cell death, reduces the inflammation, and prolongs mouse survival, whereas Ripk3 loss alone offers little benefit. Residual inflammation in mice lacking cIap1/2, Casp8, and Ripk3 is reduced by inhibition of NIK. Loss of Casp8 and Mlkl (mixed lineage kinase domain-like), but not Mlkl loss alone, also prevents cIAP1/2-deficient mice from dying around embryonic day 11. Therefore, a major function of cIAP1/2 in vivo is to suppress caspase-8-dependent cell death." @default.
- W2947352613 created "2019-06-07" @default.
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- W2947352613 date "2019-05-01" @default.
- W2947352613 modified "2023-10-09" @default.
- W2947352613 title "Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation" @default.
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- W2947352613 cites W1857408336 @default.
- W2947352613 cites W1963848568 @default.
- W2947352613 cites W1970186446 @default.
- W2947352613 cites W1974139441 @default.
- W2947352613 cites W1975593978 @default.
- W2947352613 cites W1987057890 @default.
- W2947352613 cites W1987241739 @default.
- W2947352613 cites W1988376074 @default.
- W2947352613 cites W1993613360 @default.
- W2947352613 cites W1993731501 @default.
- W2947352613 cites W1998423564 @default.
- W2947352613 cites W2001879129 @default.
- W2947352613 cites W2005572311 @default.
- W2947352613 cites W2006273251 @default.
- W2947352613 cites W2007102240 @default.
- W2947352613 cites W2022247016 @default.
- W2947352613 cites W2026512029 @default.
- W2947352613 cites W2032514624 @default.
- W2947352613 cites W2033562377 @default.
- W2947352613 cites W2033703058 @default.
- W2947352613 cites W2033812051 @default.
- W2947352613 cites W2033914606 @default.
- W2947352613 cites W2036528355 @default.
- W2947352613 cites W2042577315 @default.
- W2947352613 cites W2043880988 @default.
- W2947352613 cites W2045806492 @default.
- W2947352613 cites W2045991166 @default.
- W2947352613 cites W2048588387 @default.
- W2947352613 cites W2049226548 @default.
- W2947352613 cites W2052605153 @default.
- W2947352613 cites W2052740597 @default.
- W2947352613 cites W2060945380 @default.
- W2947352613 cites W2063548806 @default.
- W2947352613 cites W2064299413 @default.
- W2947352613 cites W2073807266 @default.
- W2947352613 cites W2085018432 @default.
- W2947352613 cites W2089276791 @default.
- W2947352613 cites W2090903823 @default.
- W2947352613 cites W2091269867 @default.
- W2947352613 cites W2092585655 @default.
- W2947352613 cites W2097724407 @default.
- W2947352613 cites W2099760505 @default.
- W2947352613 cites W2106332058 @default.
- W2947352613 cites W2125548716 @default.
- W2947352613 cites W2129627069 @default.
- W2947352613 cites W2130776456 @default.
- W2947352613 cites W2135332272 @default.
- W2947352613 cites W2149998180 @default.
- W2947352613 cites W2151861156 @default.
- W2947352613 cites W2157182132 @default.
- W2947352613 cites W2163966171 @default.
- W2947352613 cites W2166793740 @default.
- W2947352613 cites W2169930621 @default.
- W2947352613 cites W2188984095 @default.
- W2947352613 cites W2343275849 @default.
- W2947352613 cites W2397501040 @default.
- W2947352613 cites W2510683315 @default.
- W2947352613 cites W2515679818 @default.
- W2947352613 cites W2547118804 @default.
- W2947352613 cites W2574819148 @default.
- W2947352613 cites W2608687752 @default.
- W2947352613 cites W2613123103 @default.
- W2947352613 cites W2620769476 @default.
- W2947352613 cites W2704191306 @default.
- W2947352613 cites W2755384228 @default.
- W2947352613 cites W2770069282 @default.
- W2947352613 cites W2783531257 @default.
- W2947352613 cites W2790995801 @default.
- W2947352613 cites W2810440345 @default.
- W2947352613 cites W2888164914 @default.
- W2947352613 cites W2888515069 @default.
- W2947352613 cites W2889681607 @default.
- W2947352613 cites W2898289679 @default.
- W2947352613 cites W2898732430 @default.
- W2947352613 cites W2900410132 @default.
- W2947352613 doi "https://doi.org/10.1016/j.celrep.2019.04.111" @default.
- W2947352613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31141691" @default.
- W2947352613 hasPublicationYear "2019" @default.
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