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• W2947356009 abstract "e15530 Background: Peritoneal metastases are the most common recurrence of gastric cancer, even after radical surgery. Urokinase-type plasminogen activator (uPA) system, including its receptor uPAR, is crucial in the proteolysis activation for the cleavage of the extracellular matrix and basement membrane. The purpose of the study was to determine the antigen form uPA-Ag, active form uPA-act and the uPAR receptor in tissues of adenocarcinoma of the stomach, its perifocal tissues (PT), greater omentum and peritoneum in patients with stomach cancer T 3-4 а N 0-3 M 1 and T 3-4 а N 0-3 M 0 . Methods: Tissues of patients with gastric adenocarcinoma T 3-4 а N 0-3 M 1 (n = 21: 10 men, 11 women) and T 3-4 а N 0-3 M 0 (n = 24: 15 men, 9 women) aged 61.23±4.8 years were studied. Controls: non-cancer patients aged 39.1±3.2 years (n = 17: 6 men, 11 women). Levels of uPA-act, uPA-Ag and uPAR were determined by ELISA using standard test systems. Statistical analysis was performed using the SPSS 11.5 software package for Windows. Results: In T 3-4 а N 0-3 M 1 , the highest uPAR levels were observed in tissues of the tumor, greater omentum and peritoneum, compared to T 3-4 а N 0-3 M 0 and controls (p < 0.01). In PT of T 3-4 а N 0-3 M 1 , uPAR levels were lower than in tumor (p < 0.01) but higher than in resection line tissues. Tumor levels of uPA-act in T 3-4 а N 0-3 M 1 and T 3-4 а N 0-3 M 0 were similar and in both cases higher than in PT. In the greater omentum in T 3-4 а N 0-3 M 1 , uPA-act levels were similar to tumor levels and exceeded the values in T 3-4 а N 0-3 M 0 (p < 0.01). Peritoneal uPA-act did not differ in T 3-4 а N 0-3 M 1 and T 3-4 а N 0-3 M 0 but was higher than in controls (p < 0.05). Tumor levels of uPA-Ag in T 3-4 а N 0-3 M 1 exceeded the levels in T 3-4 а N 0-3 M 0 and in both PT (p < 0.05). Levels of uPA-Ag in the greater omentum in T 3-4 а N 0-3 M 1 were higher than in T 3-4 а N 0-3 M 0 and lower than in controls (p < 0.01). Comparable uPA-Ag levels in T 3-4 а N 0-3 M 1 and T 3-4 а N 0-3 M 0 were lower than in controls (p < 0.01). Conclusions: Gastric adenocarcinoma secretes uPAR and uPA, and uPAR levels in the tumor are associated with omental or peritoneal metastases. Levels of uPAR and uPA-act in the greater omentum and peritoneum in T 3-4 а N 0-3 M 1 are increased even higher than in T 3-4 а N 0-3 M 0 ; uPAR can serve as a marker of a pre-metastatic niche in peritoneal tissues." @default.
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• W2947356009 date "2019-05-20" @default.
• W2947356009 modified "2023-10-03" @default.
• W2947356009 title "Distribution of urokinase-type plasminogen activator and its receptor in malignant tissues of gastric adenocarcinoma." @default.
• W2947356009 doi "https://doi.org/10.1200/jco.2019.37.15_suppl.e15530" @default.
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