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• W2947376813 abstract "The randomized trial PRODIGE 7 failed to show the benefit of oxaliplatin hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal peritoneal metastasis treatment (CR PM). This systematic review focuses on the association of cisplatin (CDDP) with mitomycin C (MMC) in HIPEC in CR PM.Experimental studies demonstrated that hyperthermia, in addition to CDDP ± MMC treatment, gradually improved the cytotoxic effect by increasing early apoptosis, eATP interaction, intracellular CDDP concentration (by 20%) and p73 expression. Recent studies with highly selected patients reported unusual prolonged survival with a median overall survival (OS) of approximately 60 months, with a HIPEC combination of CDDP (25 mg/m2/L) plus MMC (3.3 mg/m2/L) at a temperature of 41.5-42.5 °C for 60-90 min. Major complications occurred in less than 30% of patients with limited hematological toxicity (less than 15%). In addition, in a phase 2 trial, an adjuvant HIPEC benefit was demonstrated in colorectal cancer patients with high risk for peritoneal failure (5-year OS: 81.3% vs. 70% for the HIPEC group vs. the control group, respectively, p=0.047). After a recurrence, an iterative procedure permitted similar recurrence-free disease (13 vs. 13.7 months) with an acceptable morbidity (18.7% of severe complications).The combination of CDDP and MMC seems to be an interesting protocol as an alternative to high-dose and short-term oxaliplatin." @default.
• W2947376813 created "2019-06-07" @default.
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• W2947376813 date "2019-05-29" @default.
• W2947376813 modified "2023-09-24" @default.
• W2947376813 title "Hyperthermic intraperitoneal chemotherapy with cisplatin and mitomycin C for colorectal cancer peritoneal metastases: A systematic review of the literature" @default.
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• W2947376813 doi "https://doi.org/10.1515/pp-2019-0006" @default.
• W2947376813 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6668656" @default.
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• W2947376813 hasPublicationYear "2019" @default.
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