Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947377923> ?p ?o ?g. }
- W2947377923 endingPage "6486" @default.
- W2947377923 startingPage "6476" @default.
- W2947377923 abstract "This work aims to improve the antiarthritic activity of (−)-epigallocatechin gallate (EGCG) and glucosamine (GA) through fabrication and optimization of casein protein nanoparticles (EGC-NPs). Optimized EGC-NPs were obtained with a EGCG/GA/casein ratio of 1:2:8 (w/w/w). The EGC-NPs gave a mean size of 186 ± 3.5 nm and an entrapment efficiency of 86.8 ± 2.7%, and they exhibited a greater inhibitory activity against human fibroblast-like synoviocytes-osteoarthritis cells and human fibroblast-like synoviocytes-rheumatoid arthritis cells compared with that of the EGCG-GA mixture by 33.5% and 20.8%, respectively. Freeze-dried EGC-NPs stored at 25 °C during 12 months showed high dispersion stability. Moreover, the redispersion of the freeze-dried EGC-NPs produced almost no significant changes in their physicochemical properties and bioactivity. Rat experiments demonstrated that the antiarthritis effect of the EGC-NPs was significantly higher than that of EGCG-GA mixture, as assessed through an analysis of anti-inflammatory efficacy, radiographic images and histopathological assessments of paw joints, and immunohistochemical changes in serum cytokines. The enchanced antiarthritic activity in vivo was consistent with that in vitro. The EGC-NPs demonstrate potential as a food supplement for the treatment of arthritis." @default.
- W2947377923 created "2019-06-07" @default.
- W2947377923 creator A5005441350 @default.
- W2947377923 creator A5025220046 @default.
- W2947377923 creator A5027529901 @default.
- W2947377923 creator A5034408688 @default.
- W2947377923 creator A5040400409 @default.
- W2947377923 creator A5058373201 @default.
- W2947377923 creator A5060413216 @default.
- W2947377923 creator A5065390597 @default.
- W2947377923 creator A5083682185 @default.
- W2947377923 date "2019-05-22" @default.
- W2947377923 modified "2023-09-30" @default.
- W2947377923 title "Enhanced Antiarthritic Efficacy by Nanoparticles of (−)-Epigallocatechin Gallate–Glucosamine–Casein" @default.
- W2947377923 cites W1852190768 @default.
- W2947377923 cites W1964342138 @default.
- W2947377923 cites W1964701409 @default.
- W2947377923 cites W1965484815 @default.
- W2947377923 cites W1970432992 @default.
- W2947377923 cites W1980706354 @default.
- W2947377923 cites W1981511795 @default.
- W2947377923 cites W1983767980 @default.
- W2947377923 cites W1984723203 @default.
- W2947377923 cites W1985938755 @default.
- W2947377923 cites W1991388661 @default.
- W2947377923 cites W1992625772 @default.
- W2947377923 cites W1996013696 @default.
- W2947377923 cites W2005260135 @default.
- W2947377923 cites W2015246829 @default.
- W2947377923 cites W2017015410 @default.
- W2947377923 cites W2017372504 @default.
- W2947377923 cites W2037870681 @default.
- W2947377923 cites W2038773696 @default.
- W2947377923 cites W2042237966 @default.
- W2947377923 cites W2046342352 @default.
- W2947377923 cites W2047332892 @default.
- W2947377923 cites W2051446426 @default.
- W2947377923 cites W2055834145 @default.
- W2947377923 cites W2062454378 @default.
- W2947377923 cites W2069481878 @default.
- W2947377923 cites W2070436907 @default.
- W2947377923 cites W2087784139 @default.
- W2947377923 cites W2094983273 @default.
- W2947377923 cites W2099489843 @default.
- W2947377923 cites W2122497740 @default.
- W2947377923 cites W2124790232 @default.
- W2947377923 cites W2125552828 @default.
- W2947377923 cites W2126904402 @default.
- W2947377923 cites W2130513475 @default.
- W2947377923 cites W2148799855 @default.
- W2947377923 cites W2155440550 @default.
- W2947377923 cites W2249267412 @default.
- W2947377923 cites W2268353706 @default.
- W2947377923 cites W2273866001 @default.
- W2947377923 cites W2295608765 @default.
- W2947377923 cites W2319461026 @default.
- W2947377923 cites W2331839753 @default.
- W2947377923 cites W2333411823 @default.
- W2947377923 cites W2514626603 @default.
- W2947377923 cites W2571845962 @default.
- W2947377923 cites W2616508022 @default.
- W2947377923 cites W2766028903 @default.
- W2947377923 cites W2766507639 @default.
- W2947377923 cites W2909770765 @default.
- W2947377923 doi "https://doi.org/10.1021/acs.jafc.9b02075" @default.
- W2947377923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31117504" @default.
- W2947377923 hasPublicationYear "2019" @default.
- W2947377923 type Work @default.
- W2947377923 sameAs 2947377923 @default.
- W2947377923 citedByCount "25" @default.
- W2947377923 countsByYear W29473779232019 @default.
- W2947377923 countsByYear W29473779232020 @default.
- W2947377923 countsByYear W29473779232021 @default.
- W2947377923 countsByYear W29473779232022 @default.
- W2947377923 countsByYear W29473779232023 @default.
- W2947377923 crossrefType "journal-article" @default.
- W2947377923 hasAuthorship W2947377923A5005441350 @default.
- W2947377923 hasAuthorship W2947377923A5025220046 @default.
- W2947377923 hasAuthorship W2947377923A5027529901 @default.
- W2947377923 hasAuthorship W2947377923A5034408688 @default.
- W2947377923 hasAuthorship W2947377923A5040400409 @default.
- W2947377923 hasAuthorship W2947377923A5058373201 @default.
- W2947377923 hasAuthorship W2947377923A5060413216 @default.
- W2947377923 hasAuthorship W2947377923A5065390597 @default.
- W2947377923 hasAuthorship W2947377923A5083682185 @default.
- W2947377923 hasConcept C126322002 @default.
- W2947377923 hasConcept C13965031 @default.
- W2947377923 hasConcept C142724271 @default.
- W2947377923 hasConcept C150903083 @default.
- W2947377923 hasConcept C185592680 @default.
- W2947377923 hasConcept C202751555 @default.
- W2947377923 hasConcept C204787440 @default.
- W2947377923 hasConcept C207001950 @default.
- W2947377923 hasConcept C2776142715 @default.
- W2947377923 hasConcept C2776164576 @default.
- W2947377923 hasConcept C2777192995 @default.
- W2947377923 hasConcept C2777575956 @default.
- W2947377923 hasConcept C2778004101 @default.