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• W2947418504 startingPage "1585" @default.
• W2947418504 abstract "Abstract Mutations in the β‐carotene oxygenase 2 (BCO2) gene can impair the function of the enzyme that breaks down carotenoids. As a result, gradual accumulation of unoxidized carotenoids in animal tissues gives them a yellow colour. The aim of the study was to determine the content of carotenoids, retinol and α‐tocopherol in the liver, fat and milk of rabbit does with three different genotypes determined by AAT‐deletion mutation at codon 248 of the BCO2 gene and to find out whether differences in the concentrations of the above compounds in the tissues and milk of the does affect reproduction parameters and the rearing rate of kittens. The experimental materials comprised 36 does, 12 of each genotype of the BCO2 gene, with their litters. Females with their litters were placed in individual cages, on deep litter. Between days 7 and 13 of lactation, samples of milk were collected from the does. The kittens stayed with their mothers until 35 days of age. After weaning, the does were sacrificed. Tissue samples of liver and perirenal fat were collected for chemical analyses. Additionally, based on samples taken from one female, RNA expression levels were determined from the mammary gland and liver, adipose tissue and skin. It was found that homozygous does with deletion at codon 248 of the BCO2 gene were characterized by considerably higher concentrations of xanthophylls and beta‐carotene in the liver, adipose tissue and milk than does with the remaining genotypes. However, the differences in the content of the above compounds in milk had no influence on litter weight or the number and rearing rate of kittens. Additionally, RNA expression of the BCO2 gene was found in the mammary tissue of lactating doe and its level was similar to those noted in the liver and adipose tissue." @default.
• W2947418504 created "2019-06-07" @default.
• W2947418504 creator A5034461637 @default.
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• W2947418504 date "2019-05-29" @default.
• W2947418504 modified "2023-10-16" @default.
• W2947418504 title "Effect of the β‐carotene oxygenase 2 genotype on the content of carotenoids, retinol and α‐tocopherol in the liver, fat and milk of rabbit does, reproduction parameters and kitten growth" @default.
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• W2947418504 doi "https://doi.org/10.1111/jpn.13130" @default.
• W2947418504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31141232" @default.
• W2947418504 hasPublicationYear "2019" @default.
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