Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947440113> ?p ?o ?g. }
- W2947440113 endingPage "10289" @default.
- W2947440113 startingPage "10284" @default.
- W2947440113 abstract "Abstract 2‐Oxazolidinones are saturated heterocyclic compounds, which are highly attractive targets in modern drug design. Herein, we describe a new, single‐step approach to 3,4‐disubstituted 2‐oxazolidinones by aza‐Michael addition using CO 2 as a carbonyl source and 1,1,3,3‐tetramethylguanidine (TMG) as a catalyst. The modular reaction, which occurs between a γ‐brominated Michael acceptor, CO 2 and an arylamine, aliphatic amine or phenylhydrazine, is performed under mild conditions. The regiospecific reaction displays good yields (av. 75 %) and excellent functional‐group compatibility. In addition, late‐stage functionalization of drug and drug‐like molecules is demonstrated. The experimental results suggest a mechanism consisting of several elementary steps: TMG‐assisted carboxylation of aniline; generation of an O ‐alkyl carbamate; and the final ring‐forming step through an intramolecular aza‐Michael addition." @default.
- W2947440113 created "2019-06-07" @default.
- W2947440113 creator A5012668992 @default.
- W2947440113 creator A5015497870 @default.
- W2947440113 creator A5030844947 @default.
- W2947440113 creator A5043452704 @default.
- W2947440113 creator A5047350395 @default.
- W2947440113 creator A5066523104 @default.
- W2947440113 creator A5085436208 @default.
- W2947440113 date "2019-07-24" @default.
- W2947440113 modified "2023-10-11" @default.
- W2947440113 title "One‐Step Synthesis of 3,4‐Disubstituted 2‐Oxazolidinones by Base‐Catalyzed CO <sub>2</sub> Fixation and Aza‐Michael Addition" @default.
- W2947440113 cites W1966316733 @default.
- W2947440113 cites W1969487950 @default.
- W2947440113 cites W1978463739 @default.
- W2947440113 cites W1994741655 @default.
- W2947440113 cites W2004983760 @default.
- W2947440113 cites W2007475277 @default.
- W2947440113 cites W2009403434 @default.
- W2947440113 cites W2021282327 @default.
- W2947440113 cites W2050051899 @default.
- W2947440113 cites W2053394669 @default.
- W2947440113 cites W2066056583 @default.
- W2947440113 cites W2068773401 @default.
- W2947440113 cites W2070127123 @default.
- W2947440113 cites W2074274985 @default.
- W2947440113 cites W2075355440 @default.
- W2947440113 cites W2078563256 @default.
- W2947440113 cites W2082034588 @default.
- W2947440113 cites W2096042294 @default.
- W2947440113 cites W2143786105 @default.
- W2947440113 cites W2145276181 @default.
- W2947440113 cites W2155753425 @default.
- W2947440113 cites W2231098395 @default.
- W2947440113 cites W2247581895 @default.
- W2947440113 cites W2257674076 @default.
- W2947440113 cites W2264719596 @default.
- W2947440113 cites W2276045515 @default.
- W2947440113 cites W2283686189 @default.
- W2947440113 cites W2286108466 @default.
- W2947440113 cites W2286931814 @default.
- W2947440113 cites W2287468570 @default.
- W2947440113 cites W2321174248 @default.
- W2947440113 cites W2324528752 @default.
- W2947440113 cites W2331786801 @default.
- W2947440113 cites W2334177097 @default.
- W2947440113 cites W2340901723 @default.
- W2947440113 cites W2343575251 @default.
- W2947440113 cites W2407040666 @default.
- W2947440113 cites W2472158375 @default.
- W2947440113 cites W2473655956 @default.
- W2947440113 cites W2498079106 @default.
- W2947440113 cites W2517057838 @default.
- W2947440113 cites W2580679137 @default.
- W2947440113 cites W2592502647 @default.
- W2947440113 cites W2593192738 @default.
- W2947440113 cites W2742348419 @default.
- W2947440113 cites W2751242089 @default.
- W2947440113 cites W2755776312 @default.
- W2947440113 cites W2763299322 @default.
- W2947440113 cites W2789366878 @default.
- W2947440113 cites W2792037111 @default.
- W2947440113 cites W2807988274 @default.
- W2947440113 cites W2888209246 @default.
- W2947440113 cites W3148565635 @default.
- W2947440113 cites W4244015042 @default.
- W2947440113 cites W4255063035 @default.
- W2947440113 doi "https://doi.org/10.1002/chem.201902451" @default.
- W2947440113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31141227" @default.
- W2947440113 hasPublicationYear "2019" @default.
- W2947440113 type Work @default.
- W2947440113 sameAs 2947440113 @default.
- W2947440113 citedByCount "13" @default.
- W2947440113 countsByYear W29474401132020 @default.
- W2947440113 countsByYear W29474401132021 @default.
- W2947440113 countsByYear W29474401132022 @default.
- W2947440113 countsByYear W29474401132023 @default.
- W2947440113 crossrefType "journal-article" @default.
- W2947440113 hasAuthorship W2947440113A5012668992 @default.
- W2947440113 hasAuthorship W2947440113A5015497870 @default.
- W2947440113 hasAuthorship W2947440113A5030844947 @default.
- W2947440113 hasAuthorship W2947440113A5043452704 @default.
- W2947440113 hasAuthorship W2947440113A5047350395 @default.
- W2947440113 hasAuthorship W2947440113A5066523104 @default.
- W2947440113 hasAuthorship W2947440113A5085436208 @default.
- W2947440113 hasBestOaLocation W29474401132 @default.
- W2947440113 hasConcept C112423150 @default.
- W2947440113 hasConcept C131779359 @default.
- W2947440113 hasConcept C161790260 @default.
- W2947440113 hasConcept C178790620 @default.
- W2947440113 hasConcept C185592680 @default.
- W2947440113 hasConcept C21951064 @default.
- W2947440113 hasConcept C2779244968 @default.
- W2947440113 hasConcept C75079739 @default.
- W2947440113 hasConceptScore W2947440113C112423150 @default.
- W2947440113 hasConceptScore W2947440113C131779359 @default.
- W2947440113 hasConceptScore W2947440113C161790260 @default.
- W2947440113 hasConceptScore W2947440113C178790620 @default.