FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947442823> ?p ?o ?g. }

• W2947442823 endingPage "11" @default.
• W2947442823 startingPage "1" @default.
• W2947442823 abstract "According to the oxidative-inflammatory theory of aging, there is a link between the function, the oxidative-inflammatory stress state of immune cells, and longevity. However, it is unknown which immune cell parameters can predict lifespan and if there would be any changes in this prediction, depending on the age of the subject. Therefore, a longitudinal study in mice was performed analysing immune function (chemotaxis of macrophages and lymphocytes, phagocytosis of macrophages, natural killer (NK) activity, and lymphoproliferation capacity), antioxidant (catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities as well as reduced glutathione (GSH) concentrations), oxidant (oxidized glutathione (GSSG), superoxide anion, and malondialdehyde (MDA) concentrations), and inflammation-related markers (basal release of IL-1 β , IL-6, TNF- α , and IL-10) in peritoneal leukocytes from mice at the adult, mature, old, very old, and long-lived ages (40, 56, 72, 96, and <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn>120</mml:mn><mml:mo>±</mml:mo><mml:mn>4</mml:mn></mml:math> weeks of age, respectively). The results reveal that some of the investigated parameters are determinants of longevity at the adult age (lymphoproliferative capacity, lymphocyte chemotaxis, macrophage chemotaxis and phagocytosis, GPx activity, and GSH, MDA, IL-6, TNF- α , and IL-10 concentrations), and therefore, they could be proposed as markers of the rate of aging. However, other parameters are predictive of extreme longevity only at the very old age (NK activity, CAT and GR activities, and IL-6 and IL-1 β concentrations), and as such, they could reflect some of the adaptive mechanisms underlying the achievement of high longevity. Nevertheless, although preliminary, the results of the present study provide a new perspective on the use of function, redox, and inflammatory parameters in immune cells as prognostic tools in aging research and represent a novel benchmark for future work aimed at prediction of lifespan." @default.
• W2947442823 created "2019-06-07" @default.
• W2947442823 creator A5003510265 @default.
• W2947442823 creator A5035803982 @default.
• W2947442823 creator A5063424030 @default.
• W2947442823 creator A5091459718 @default.
• W2947442823 date "2019-06-02" @default.
• W2947442823 modified "2023-10-12" @default.
• W2947442823 title "Function, Oxidative, and Inflammatory Stress Parameters in Immune Cells as Predictive Markers of Lifespan throughout Aging" @default.
• W2947442823 cites W1583921993 @default.
• W2947442823 cites W1598853369 @default.
• W2947442823 cites W1640740682 @default.
• W2947442823 cites W1973481434 @default.
• W2947442823 cites W1989155511 @default.
• W2947442823 cites W1996127285 @default.
• W2947442823 cites W2018561003 @default.
• W2947442823 cites W2023295845 @default.
• W2947442823 cites W2032259817 @default.
• W2947442823 cites W2042684962 @default.
• W2947442823 cites W2063954678 @default.
• W2947442823 cites W2082402714 @default.
• W2947442823 cites W2097684377 @default.
• W2947442823 cites W2109643174 @default.
• W2947442823 cites W2122816074 @default.
• W2947442823 cites W2127489819 @default.
• W2947442823 cites W2157420210 @default.
• W2947442823 cites W2158226607 @default.
• W2947442823 cites W2164310494 @default.
• W2947442823 cites W2315512556 @default.
• W2947442823 cites W2320203427 @default.
• W2947442823 cites W2558085743 @default.
• W2947442823 cites W2566688801 @default.
• W2947442823 cites W2593550311 @default.
• W2947442823 cites W2739265123 @default.
• W2947442823 cites W2761559198 @default.
• W2947442823 cites W2783843845 @default.
• W2947442823 cites W2794019774 @default.
• W2947442823 cites W2800578025 @default.
• W2947442823 cites W2905444998 @default.
• W2947442823 cites W2912022405 @default.
• W2947442823 doi "https://doi.org/10.1155/2019/4574276" @default.
• W2947442823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6589234" @default.
• W2947442823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31281577" @default.
• W2947442823 hasPublicationYear "2019" @default.
• W2947442823 type Work @default.
• W2947442823 sameAs 2947442823 @default.
• W2947442823 citedByCount "21" @default.
• W2947442823 countsByYear W29474428232020 @default.
• W2947442823 countsByYear W29474428232021 @default.
• W2947442823 countsByYear W29474428232022 @default.
• W2947442823 countsByYear W29474428232023 @default.
• W2947442823 crossrefType "journal-article" @default.
• W2947442823 hasAuthorship W2947442823A5003510265 @default.
• W2947442823 hasAuthorship W2947442823A5035803982 @default.
• W2947442823 hasAuthorship W2947442823A5063424030 @default.
• W2947442823 hasAuthorship W2947442823A5091459718 @default.
• W2947442823 hasBestOaLocation W29474428231 @default.
• W2947442823 hasConcept C134018914 @default.
• W2947442823 hasConcept C160448771 @default.
• W2947442823 hasConcept C165069038 @default.
• W2947442823 hasConcept C181199279 @default.
• W2947442823 hasConcept C185592680 @default.
• W2947442823 hasConcept C203014093 @default.
• W2947442823 hasConcept C2776151105 @default.
• W2947442823 hasConcept C2776914184 @default.
• W2947442823 hasConcept C2778401633 @default.
• W2947442823 hasConcept C2778760513 @default.
• W2947442823 hasConcept C2778979269 @default.
• W2947442823 hasConcept C2779056147 @default.
• W2947442823 hasConcept C538909803 @default.
• W2947442823 hasConcept C55493867 @default.
• W2947442823 hasConcept C86803240 @default.
• W2947442823 hasConcept C8891405 @default.
• W2947442823 hasConceptScore W2947442823C134018914 @default.
• W2947442823 hasConceptScore W2947442823C160448771 @default.
• W2947442823 hasConceptScore W2947442823C165069038 @default.
• W2947442823 hasConceptScore W2947442823C181199279 @default.
• W2947442823 hasConceptScore W2947442823C185592680 @default.
• W2947442823 hasConceptScore W2947442823C203014093 @default.
• W2947442823 hasConceptScore W2947442823C2776151105 @default.
• W2947442823 hasConceptScore W2947442823C2776914184 @default.
• W2947442823 hasConceptScore W2947442823C2778401633 @default.
• W2947442823 hasConceptScore W2947442823C2778760513 @default.
• W2947442823 hasConceptScore W2947442823C2778979269 @default.
• W2947442823 hasConceptScore W2947442823C2779056147 @default.
• W2947442823 hasConceptScore W2947442823C538909803 @default.
• W2947442823 hasConceptScore W2947442823C55493867 @default.
• W2947442823 hasConceptScore W2947442823C86803240 @default.
• W2947442823 hasConceptScore W2947442823C8891405 @default.
• W2947442823 hasFunder F4320335322 @default.
• W2947442823 hasLocation W29474428231 @default.
• W2947442823 hasLocation W29474428232 @default.
• W2947442823 hasLocation W29474428233 @default.
• W2947442823 hasLocation W29474428234 @default.
• W2947442823 hasLocation W29474428235 @default.
• W2947442823 hasOpenAccess W2947442823 @default.
• W2947442823 hasPrimaryLocation W29474428231 @default.
• W2947442823 hasRelatedWork W1967937873 @default.

• next