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• W2947446912 abstract "Purpose Palonosetron, a second-generation 5-hydroxytryptamine 3 receptor antagonist (5-HT3RA), has unique characteristics relative to first-generation 5-HT3RAs such as ondansetron. Nevertheless, it remains unclear if palonosetron is better than ondansetron for the prevention of nausea and vomiting during the first 24 hr after surgery and is thus the focus of this systematic review. Methods We conducted a systematic search of the MEDLINE , EMBASE, Cochrane Central Register of Controlled Trials and Web of Science databases to identify randomized controlled trials (RCTs) that addressed a comparison of the prophylactic antiemetic efficacy between palonosetron and ondansetron within 24 hr after surgery. The primary outcomes were the proportion of participants who experienced postoperative nausea (PON), postoperative vomiting (POV), or both, in the early (0-6 hr) or late (6-24 hr) period. The pooled relative risks (RRs) were calculated along with their corresponding 95% confidence intervals (CIs). Results We identified nine RCTs that comprised 741 participants. Palonosetron was superior to ondansetron in the reduction of early PON [RR, 0.51; 95% CI, 0.37 to 0.71], late PON (RR, 0.53; 95% CI, 0.36 to 0.77), and late POV (RR, 0.41; 95% CI, 0.28 to 0.62), but not early POV (RR, 0.77; 95% CI, 0.45 to 1.34). Conclusion Palonosetron provides more effective prophylaxis of early PON, late PON, and late POV compared with ondansetron. Future studies are required to investigate the role of palonosetron during 24-72 hr following surgery. Resume Objectif Le palonosetron est un antagoniste du recepteur de la 5-hydroxytryptamine 3 (5-HT3RA) de deuxieme generation; il presente des caracteristiques uniques par rapport aux 5-HT3RA de premiere generation tels que l’ondansetron. Neanmoins, il n’est pas certain que le palonosetron est meilleur que l’ondansetron pour la prevention des nausees et vomissements au cours des 24 premieres heures suivant une chirurgie et cela est donc l’objet de cette revue systematique. Methodes Nous avons effectue une recherche systematique dans les bases de donnees MEDLINE , Author contributions Chao Xiong and Anshi Wu were involved in the design of the study. Anshi Wu was involved in the conception of the study. Chao Xiong and Guangyu Liu helped extract the data. Chao Xiong, Guangyu Liu, and Jixiu Xue helped analyze and interpret the study data. Chao Xiong, Guangyu Liu, Ruolan Ma, and Jixiu Xue helped draft the article. Ruolan Ma was involved in the statistical analysis raised by the reviewers and in modifying the analysis part of the Method and Results sections. Ruolan Ma and Jixiu Xue were involved in checking the study data. Chao Xiong and Guangyu Liu contributed equally to the study. Anshi Wu helped critically revise the manuscript. Electronic supplementary material The online version of this article (doi:10.1007/s12630-015-0457-1) contains supplementary material, which is available to authorized users. C. Xiong, MD A. Wu, MD (&) Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongtinan Road, Chaoyang District, Beijing 100020, China e-mail: wuanshi1965@163.com G. Liu, MD J. Xue, MD Department of Anesthesiology, Xuan Wu Hospital, Capital Medical University, Beijing, China R. Ma, MD Department of Anesthesiology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China 123 Can J Anesth/J Can Anesth (2015) 62:1268–1278 DOI 10.1007/s12630-015-0457-1" @default.
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• W2947446912 title "Efficacy of palonosetron for preventing postoperative nausea and vomiting: a systematic review and meta-analysis Efficacité du palonosétron pour la prévention des nausées et vomissements postopératoires: une revue systématique de la littérature et méta-analyse" @default.
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