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- W2947463402 abstract "Acute lung injury (ALI) is a severe acute inflammatory reaction of the lungs caused by a variety of factors, which can lead to a high mortality rate. MicroRNAs are a novel therapeutic molecule that play a vital role in many diseases. However, its mechanism of action in lipopolysaccharide (LPS)-induced mouse ALI is not clear. The study aimed to investigate the mechanism of action of miR-497 in LPS-induced ALI. As a result, it was found that the expression of miR-497 in the inflammatory reaction showed a decrease in time and dose trends. Importantly, miR-497 reduced LPS-induced expression levels of related inflammatory factors. In addition, we also demonstrated that IRAK2 is a direct target molecule of miR-497. Interestingly, we further found that miR-497 inhibits the expression of IRAK2 by targeting IRAK2-3'UTR. Therefore, miR-497 can partially negatively regulate the activation of IRAK2-NF-κB pathway in LPS-induced inflammatory responses." @default.
- W2947463402 created "2019-06-07" @default.
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- W2947463402 date "2019-05-30" @default.
- W2947463402 modified "2023-09-23" @default.
- W2947463402 title "miR‐497a‐5p attenuates lipopolysaccharide‐induced inflammatory injury by targeting IRAK2" @default.
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- W2947463402 doi "https://doi.org/10.1002/jcp.28850" @default.
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