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- W2947466678 abstract "Abstract Background Rheumatoid Arthritis (RA) is a chronic inflammatory disease, affecting women more than men, with a more aggressive course in women. Design A prospective study that recruited 58 patients (46 women aged 56 ± 12 years) with active long-standing RA disease (>12 months). Our goals were to measure their endothelial function, part of the cardiovascular risk assessment. Methods The Brachial Artery method measured endothelial function (the flow mediated percent change [FMD percentage] of the brachial artery diameter). A senior Rheumatologist clinically evaluated all subjects. Mann Whitney rank sum test estimated gender differences among the RA patients. Results Median FMD% change for men was −6.07%, while median FMD% change for women was 0.44% (Z = 2.38, P = 0.01). Baseline Brachial artery diameter was larger in men (Z = 2.52, P = 0.01); however, tender joints count and BMI were greater in women (Z=−2.24, P = 0.01; Z=−3.99, P = 0.001), respectively. Conclusions Women with RA have significantly better endothelial function than men with RA. It means that even though RA is 3-fold more prevalent in women, women are more protected from atherosclerotic coronary artery disease and cardiac events." @default.
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- W2947466678 date "2019-05-31" @default.
- W2947466678 modified "2023-10-01" @default.
- W2947466678 title "Gender differences in cardiovascular risk of patients with rheumatoid arthritis" @default.
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- W2947466678 doi "https://doi.org/10.1093/qjmed/hcz124" @default.
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