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• W2947474493 abstract "HTLV-1 is the first human retrovirus to have been identified and is endemic in certain areas worldwide. HTLV-1 infection leads to the development of an inflammatory disease called HAM/TSP, a myelopathy characterized by slowly progressive spastic paraparesis. There have been no effective therapeutics available for HAM/TSP, but recently, a semisynthetic glycosaminoglycan, named pentosan polysulfate (PPS), has been found to alleviate the symptoms of HAM/TSP. Here we conducted a comprehensive study on the effect of PPS both in vitro and in vivo . PPS demonstrated anti-HTLV-1 potential in infected cell lines, as shown by its suppressive effects on HTLV-1 replication and transmission and on the transmigration of infected T cells. Moreover, results obtained from two HTLV-1 mouse models demonstrate that PPS inhibits HTLV-1 infection and inflammation development in vivo . Our work offers insights into the treatment of HAM/TSP by PPS and also suggests its possible use for treating other HTLV-1-induced inflammatory diseases." @default.
• W2947474493 created "2019-06-07" @default.
• W2947474493 creator A5001399725 @default.
• W2947474493 creator A5009994116 @default.
• W2947474493 creator A5018503597 @default.
• W2947474493 creator A5019527890 @default.
• W2947474493 creator A5082609376 @default.
• W2947474493 date "2019-08-15" @default.
• W2947474493 modified "2023-09-26" @default.
• W2947474493 title "Pentosan Polysulfate Demonstrates Anti-human T-Cell Leukemia Virus Type 1 Activities <i>In Vitro</i> and <i>In Vivo</i>" @default.
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• W2947474493 doi "https://doi.org/10.1128/jvi.00413-19" @default.
• W2947474493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6675881" @default.
• W2947474493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31167921" @default.
• W2947474493 hasPublicationYear "2019" @default.
• W2947474493 type Work @default.
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• W2947474493 hasAuthorship W2947474493A5001399725 @default.
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