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• W2947477524 abstract "Pancreatic ductal adenocarcinoma (PDA) is a heterogeneous disease comprised of a basal-like subtype with mesenchymal gene signatures, undifferentiated histopathology and worse prognosis compared to the classical subtype. Despite their prognostic and therapeutic value, the key drivers that establish and control subtype identity remain unknown. Here, we demonstrate that PDA subtypes are not permanently encoded, and identify the GLI2 transcription factor as a master regulator of subtype inter-conversion. GLI2 is elevated in basal-like PDA lines and patient specimens, and forced GLI2 activation is sufficient to convert classical PDA cells to basal-like. Mechanistically, GLI2 upregulates expression of the pro-tumorigenic secreted protein, Osteopontin (OPN), which is especially critical for metastatic growth in vivo and adaptation to oncogenic KRAS ablation. Accordingly, elevated GLI2 and OPN levels predict shortened overall survival of PDA patients. Thus, the GLI2-OPN circuit is a driver of PDA cell plasticity that establishes and maintains an aggressive variant of this disease." @default.
• W2947477524 created "2019-06-07" @default.
• W2947477524 creator A5013672472 @default.
• W2947477524 creator A5013949683 @default.
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• W2947477524 creator A5066005475 @default.
• W2947477524 creator A5089743994 @default.
• W2947477524 date "2019-05-28" @default.
• W2947477524 modified "2023-10-10" @default.
• W2947477524 title "Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer" @default.
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• W2947477524 cites W1964699883 @default.
• W2947477524 cites W1968812902 @default.
• W2947477524 cites W1971298987 @default.
• W2947477524 cites W1973424072 @default.
• W2947477524 cites W1981104423 @default.
• W2947477524 cites W1985323012 @default.
• W2947477524 cites W1987313243 @default.
• W2947477524 cites W1987860480 @default.
• W2947477524 cites W1996902769 @default.
• W2947477524 cites W1996912024 @default.
• W2947477524 cites W2002355858 @default.
• W2947477524 cites W2005895632 @default.
• W2947477524 cites W2007765039 @default.
• W2947477524 cites W2010916968 @default.
• W2947477524 cites W2022514199 @default.
• W2947477524 cites W2034893372 @default.
• W2947477524 cites W2042198997 @default.
• W2947477524 cites W2044198666 @default.
• W2947477524 cites W2044702943 @default.
• W2947477524 cites W2047902687 @default.
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• W2947477524 cites W2067826589 @default.
• W2947477524 cites W2067964015 @default.
• W2947477524 cites W2068523052 @default.
• W2947477524 cites W2069269337 @default.
• W2947477524 cites W2076144924 @default.
• W2947477524 cites W2077569218 @default.
• W2947477524 cites W2086152184 @default.
• W2947477524 cites W2092536825 @default.
• W2947477524 cites W2097255042 @default.
• W2947477524 cites W2097469924 @default.
• W2947477524 cites W2098036848 @default.
• W2947477524 cites W2098820114 @default.
• W2947477524 cites W2106912046 @default.
• W2947477524 cites W2110321605 @default.
• W2947477524 cites W2120954784 @default.
• W2947477524 cites W2127362646 @default.
• W2947477524 cites W2127438438 @default.
• W2947477524 cites W2128775062 @default.
• W2947477524 cites W2132619562 @default.
• W2947477524 cites W2138155367 @default.
• W2947477524 cites W2138979073 @default.
• W2947477524 cites W2142557392 @default.
• W2947477524 cites W2144402328 @default.
• W2947477524 cites W2146177965 @default.
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• W2947477524 cites W2161884651 @default.
• W2947477524 cites W2163007274 @default.
• W2947477524 cites W2259802687 @default.
• W2947477524 cites W2285093314 @default.
• W2947477524 cites W2469106569 @default.
• W2947477524 cites W2470222015 @default.
• W2947477524 cites W2518448021 @default.
• W2947477524 cites W2519938316 @default.
• W2947477524 cites W2561027268 @default.
• W2947477524 cites W2623485051 @default.
• W2947477524 cites W268810535 @default.
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• W2947477524 doi "https://doi.org/10.7554/elife.45313" @default.
• W2947477524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6538376" @default.
• W2947477524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31134896" @default.
• W2947477524 hasPublicationYear "2019" @default.
• W2947477524 type Work @default.
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