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- W2947486412 abstract "The aim of the study is to elucidate new links in the pathophysiological mechanisms of paranoid schizophrenia. ERPs to the emotionally negative stimuli and to neutral stimuli (control) were recorded in 49 patients with paranoid schizophrenia with delusions and hallucinations and in 40 healthy subjects. Methylation of gene RELN in blood was also measured in the patients and control. ERPs to emotionally negative and thus more significant to the subjects stimuli evoked similar to that in the normal subjects activation of the occipital and inferior-temporal areas 200 ms after stimulus presentation (P200) in the right hemisphere, 300 ms after stimulus presentation (P300) in the left hemisphere and 400 ms after stimulus presentation (N400) again in the right hemisphere. In patients in the responses to the significant stimuli in prefrontal and frontal areas ERPs of all components revealed the increase of the latency and the amplitude while in central and temporal areas both these parameters were decreased. Methylation of gene RELN in patients appeared to be significantly reduced in comparison with the norm. Incongruent for the excitation as well as for the inhibition processes revealed in ERPs components in the patients could be caused by epigenetic pathology of the gene RELN, its demethylation being connected with aberrant expression of the protein reelin both in the blood and in the brain. This pathology may underlie abnormal pruning of the patients in frontal areas during the puberty and in the later life possibly resulting in the disturbance of the balance between excitation and inhibition processes." @default.
- W2947486412 created "2019-06-07" @default.
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- W2947486412 date "2019-07-01" @default.
- W2947486412 modified "2023-09-27" @default.
- W2947486412 title "O-09 Some new links in the pathophysiological mechanisms of paranoid schizophrenia" @default.
- W2947486412 doi "https://doi.org/10.1016/j.clinph.2019.04.325" @default.
- W2947486412 hasPublicationYear "2019" @default.
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