FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947494089> ?p ?o ?g. }

• W2947494089 endingPage "172413" @default.
• W2947494089 startingPage "172413" @default.
• W2947494089 abstract "A characteristic of endothelia damage and repair is the turnover of extracellular matrix components. As a part of extracellular matrix glycosaminoglycan (GAG), hyaluronic acid (HA, main component of glycocalyx) is not only involved in inflammation, proliferation, differentiation of cells, and tissue remodeling, but also functions as a barrier of endothelium via preventing blood flow-induced injury from endothelial layer. Therefore, the metabolism of hyaluronic acid could allow the fine-tuning of cell behavior. In this study, we found that low shear stress decreased the expression of hyaluronic acid, whereas pretreatment with berberine could significantly increase the expression of hyaluronic acid in vitro and in vivo. On this background, it is very important to better understand the beneficial effect of berberine (BBR) on low shear stress-induced degradation of hyaluronic acid and its potential mechanism. By using siRNA and inhibitors, we testified that AMP-activated protein kinase (AMPK) and p47phox/hyaluronidase 2 (Hyal2) signaling pathway involved in the modulation of hyaluronic acid metabolism. Further, berberine, by increasing AMPK phosphorylation, decreased the dissociation of p47phox/Hyal2, and subsequently inhibited Hyal2 activation and p47phox phosphorylation, leading to the metabolic maintaining of hyaluronic acid. Importantly, we primarily demonstrated a direct binding between AMPKα and p47phox in HUVECs by co-immunoprecipitation. On the other hand, berberine also increased the expression of hyaluronic acid synthase 2 (HAS2) by regulating AMPKα/p47phox signaling pathway. Taken together, berberine treatment can attenuate low shear stress-induced hyaluronic acid degradation via increasing phosphorylation of AMPKa, and then not only downregulates p47phox and Hyal2 activity but also upregulates the expression of HAS2." @default.
• W2947494089 created "2019-06-07" @default.
• W2947494089 creator A5000977466 @default.
• W2947494089 creator A5010887322 @default.
• W2947494089 creator A5015158343 @default.
• W2947494089 creator A5015211598 @default.
• W2947494089 creator A5024475510 @default.
• W2947494089 creator A5030931393 @default.
• W2947494089 creator A5031128172 @default.
• W2947494089 creator A5062985408 @default.
• W2947494089 creator A5069575202 @default.
• W2947494089 date "2019-08-01" @default.
• W2947494089 modified "2023-09-28" @default.
• W2947494089 title "Berberine inhibits low shear stress-induced glycocalyx degradation via modulating AMPK and p47phox/Hyal2 signal pathway" @default.
• W2947494089 cites W1495287184 @default.
• W2947494089 cites W1544021262 @default.
• W2947494089 cites W1557864562 @default.
• W2947494089 cites W1964632662 @default.
• W2947494089 cites W1969395627 @default.
• W2947494089 cites W1974997758 @default.
• W2947494089 cites W1979877398 @default.
• W2947494089 cites W1982287005 @default.
• W2947494089 cites W1988230895 @default.
• W2947494089 cites W1995983036 @default.
• W2947494089 cites W2010008626 @default.
• W2947494089 cites W2011037916 @default.
• W2947494089 cites W2014742651 @default.
• W2947494089 cites W2036006678 @default.
• W2947494089 cites W2037083212 @default.
• W2947494089 cites W2045014705 @default.
• W2947494089 cites W2045025102 @default.
• W2947494089 cites W2050333516 @default.
• W2947494089 cites W2057137725 @default.
• W2947494089 cites W2058093835 @default.
• W2947494089 cites W2064030157 @default.
• W2947494089 cites W2070293380 @default.
• W2947494089 cites W2072470670 @default.
• W2947494089 cites W2076220323 @default.
• W2947494089 cites W2081278191 @default.
• W2947494089 cites W2090373595 @default.
• W2947494089 cites W2092759252 @default.
• W2947494089 cites W2098274894 @default.
• W2947494089 cites W2098866603 @default.
• W2947494089 cites W2114798850 @default.
• W2947494089 cites W2117680364 @default.
• W2947494089 cites W2119922737 @default.
• W2947494089 cites W2128466784 @default.
• W2947494089 cites W2134324252 @default.
• W2947494089 cites W2137843059 @default.
• W2947494089 cites W2146505397 @default.
• W2947494089 cites W2148464328 @default.
• W2947494089 cites W2288900222 @default.
• W2947494089 cites W2616466497 @default.
• W2947494089 cites W2885099704 @default.
• W2947494089 doi "https://doi.org/10.1016/j.ejphar.2019.172413" @default.
• W2947494089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31152700" @default.
• W2947494089 hasPublicationYear "2019" @default.
• W2947494089 type Work @default.
• W2947494089 sameAs 2947494089 @default.
• W2947494089 citedByCount "12" @default.
• W2947494089 countsByYear W29474940892020 @default.
• W2947494089 countsByYear W29474940892021 @default.
• W2947494089 countsByYear W29474940892022 @default.
• W2947494089 crossrefType "journal-article" @default.
• W2947494089 hasAuthorship W2947494089A5000977466 @default.
• W2947494089 hasAuthorship W2947494089A5010887322 @default.
• W2947494089 hasAuthorship W2947494089A5015158343 @default.
• W2947494089 hasAuthorship W2947494089A5015211598 @default.
• W2947494089 hasAuthorship W2947494089A5024475510 @default.
• W2947494089 hasAuthorship W2947494089A5030931393 @default.
• W2947494089 hasAuthorship W2947494089A5031128172 @default.
• W2947494089 hasAuthorship W2947494089A5062985408 @default.
• W2947494089 hasAuthorship W2947494089A5069575202 @default.
• W2947494089 hasBestOaLocation W29474940891 @default.
• W2947494089 hasConcept C104317684 @default.
• W2947494089 hasConcept C11960822 @default.
• W2947494089 hasConcept C185592680 @default.
• W2947494089 hasConcept C22615655 @default.
• W2947494089 hasConcept C2777529286 @default.
• W2947494089 hasConcept C2780098789 @default.
• W2947494089 hasConcept C2780116568 @default.
• W2947494089 hasConcept C2780124434 @default.
• W2947494089 hasConcept C54009773 @default.
• W2947494089 hasConcept C54355233 @default.
• W2947494089 hasConcept C55493867 @default.
• W2947494089 hasConcept C62478195 @default.
• W2947494089 hasConcept C86803240 @default.
• W2947494089 hasConcept C95444343 @default.
• W2947494089 hasConcept C97029542 @default.
• W2947494089 hasConceptScore W2947494089C104317684 @default.
• W2947494089 hasConceptScore W2947494089C11960822 @default.
• W2947494089 hasConceptScore W2947494089C185592680 @default.
• W2947494089 hasConceptScore W2947494089C22615655 @default.
• W2947494089 hasConceptScore W2947494089C2777529286 @default.
• W2947494089 hasConceptScore W2947494089C2780098789 @default.
• W2947494089 hasConceptScore W2947494089C2780116568 @default.
• W2947494089 hasConceptScore W2947494089C2780124434 @default.
• W2947494089 hasConceptScore W2947494089C54009773 @default.

• next