Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947498632> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2947498632 abstract "Telomere shortening and an increased telomerase activity are associated with poor prognosis and disease progression in many cancers. In Chronic Myeloid Leukaemia (CML) telomere shortening has a strong correlation with disease progression. Expression of hTERT, the catalytic component of telomerase, was evaluated in the CD34+ cells of CML patients. This revealed that expression of hTERT was significantly reduced in chronic phase CML and decreased with disease progression to accelerated phase and blast crisis. It could therefore be concluded that reduced hTERT expression contributes to reduced telomere length in CML. Additionally, expression of c-Myc, which increases hTERT transcription, correlated with hTERT expression suggesting decreased hTERT is partly caused by reduced c-Myc. hTERT promoter methylation and mutation status were investigated and this revealed that the hTERT promoter was not methylated and mutation rates were low suggesting that these are not contributing to reduced hTERT expression. cDNA microarrays were used to analyse gene expression in neutrophils of patients with Essential Thrombocythaemia (ET) harbouring the JAK2 V617F mutation which, like the BCR/ABL translocation in CML, results in an activated kinase. Neutrophils of ET patients exhibited a gene expression profile close to that of controls despite the presence of the mutation. Affymetrix microarrays were used to investigate the role of telomerase related genes in Myelodysplastic Syndromes (MDS). Genes decreased in patients with del(5q) include positive regulators of telomere length and genes with higher expression were associated with increased telomerase activity. Inferring that in these patients telomere length would be reduced but counteracted by increased expression of genes promoting telomerase activity. Genes that could differentiate between RA and RAEB2 subtypes were mostly related to telomere maintenance. These results demonstrate the complex role of telomerase and telomere length in malignancy and challenge the view that hTERT is always increased in cancer." @default.
- W2947498632 created "2019-06-07" @default.
- W2947498632 creator A5035298171 @default.
- W2947498632 date "2012-01-01" @default.
- W2947498632 modified "2023-09-23" @default.
- W2947498632 title "Gene Expression Analysis of Telomerase Related Genes in Myeloid Malignancy" @default.
- W2947498632 doi "https://doi.org/10.21954/ou.ro.0000f15a" @default.
- W2947498632 hasPublicationYear "2012" @default.
- W2947498632 type Work @default.
- W2947498632 sameAs 2947498632 @default.
- W2947498632 citedByCount "0" @default.
- W2947498632 crossrefType "dissertation" @default.
- W2947498632 hasAuthorship W2947498632A5035298171 @default.
- W2947498632 hasConcept C101762097 @default.
- W2947498632 hasConcept C104317684 @default.
- W2947498632 hasConcept C125593758 @default.
- W2947498632 hasConcept C150194340 @default.
- W2947498632 hasConcept C153911025 @default.
- W2947498632 hasConcept C177336024 @default.
- W2947498632 hasConcept C18431079 @default.
- W2947498632 hasConcept C2778729363 @default.
- W2947498632 hasConcept C502942594 @default.
- W2947498632 hasConcept C54355233 @default.
- W2947498632 hasConcept C86803240 @default.
- W2947498632 hasConcept C94581717 @default.
- W2947498632 hasConceptScore W2947498632C101762097 @default.
- W2947498632 hasConceptScore W2947498632C104317684 @default.
- W2947498632 hasConceptScore W2947498632C125593758 @default.
- W2947498632 hasConceptScore W2947498632C150194340 @default.
- W2947498632 hasConceptScore W2947498632C153911025 @default.
- W2947498632 hasConceptScore W2947498632C177336024 @default.
- W2947498632 hasConceptScore W2947498632C18431079 @default.
- W2947498632 hasConceptScore W2947498632C2778729363 @default.
- W2947498632 hasConceptScore W2947498632C502942594 @default.
- W2947498632 hasConceptScore W2947498632C54355233 @default.
- W2947498632 hasConceptScore W2947498632C86803240 @default.
- W2947498632 hasConceptScore W2947498632C94581717 @default.
- W2947498632 hasLocation W29474986321 @default.
- W2947498632 hasOpenAccess W2947498632 @default.
- W2947498632 hasPrimaryLocation W29474986321 @default.
- W2947498632 hasRelatedWork W1996647015 @default.
- W2947498632 hasRelatedWork W2004023747 @default.
- W2947498632 hasRelatedWork W2014255588 @default.
- W2947498632 hasRelatedWork W2043601932 @default.
- W2947498632 hasRelatedWork W2050824402 @default.
- W2947498632 hasRelatedWork W2073635566 @default.
- W2947498632 hasRelatedWork W2092054095 @default.
- W2947498632 hasRelatedWork W2096848137 @default.
- W2947498632 hasRelatedWork W2329813793 @default.
- W2947498632 hasRelatedWork W2347997826 @default.
- W2947498632 hasRelatedWork W2390380538 @default.
- W2947498632 hasRelatedWork W2416487005 @default.
- W2947498632 hasRelatedWork W248229843 @default.
- W2947498632 hasRelatedWork W2486212506 @default.
- W2947498632 hasRelatedWork W2587447252 @default.
- W2947498632 hasRelatedWork W2588497234 @default.
- W2947498632 hasRelatedWork W2724681268 @default.
- W2947498632 hasRelatedWork W2797777176 @default.
- W2947498632 hasRelatedWork W50909149 @default.
- W2947498632 hasRelatedWork W2470722876 @default.
- W2947498632 isParatext "false" @default.
- W2947498632 isRetracted "false" @default.
- W2947498632 magId "2947498632" @default.
- W2947498632 workType "dissertation" @default.