FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947500857> ?p ?o ?g. }

• W2947500857 abstract "Breast cancer resistance protein (BCRP) and multidrug resistance protein 4 (MRP4) are involved in uric acid excretion in humans and mice. Despite evidence suggesting that renal proximal tubular epithelial cells participate in uric acid excretion in chickens, the roles of BCRP and MRP4 therein remain unclear. This study evaluated the relationship between BCRP and MRP4 expression and renal function in chickens.Sixty laying hens were randomly divided into four treatment groups: a control group (NC) fed a basal diet; a sulfonamide-treated group (SD) fed the basal diet and supplemented with sulfamonomethoxine sodium via drinking water (8 mg/L); a fish meal group (FM) fed the basal diet supplemented with 16% fishmeal; and a uric acid injection group (IU) fed the basal diet and intraperitoneally injected with uric acid (250 mg/kg body weight). The results showed that serum uric acid, creatinine, and blood urea nitrogen levels were significantly higher in the SD and IU, but not FM, than in the NC groups. Renal tubular epithelial cells in the SD and IU groups were damaged. Liver BCRP and MRP4 mRNA and protein levels were significantly decreased in the SD and IU groups, but slightly increased in the FM group. In the SD group, BCRP and MRP4 were significantly increased in the ileum and slightly increased in the kidney. In the FM group, BCRP and MRP4 were significantly increased in the kidney and slightly increased in the ileum. In the IU group, BCRP and MRP4 were significantly increased in the kidney and ileum. BCRP and MRP4 expression in the jejunum was not affected by the treatments.Together, these results demonstrate that BCRP and MRP4 are involved in renal and intestinal uric acid excretion in chickens and that BCRP is positively related to MRP4 expression. Further, impairment of renal function results in an increase in serum uric acid as well as a compensatory increase in BCRP and MRP4 in the ileum; however, under normal renal function, renal BCRP and MRP4 are the main regulators of uric acid excretion." @default.
• W2947500857 created "2019-06-07" @default.
• W2947500857 creator A5006397924 @default.
• W2947500857 creator A5015358679 @default.
• W2947500857 creator A5016526551 @default.
• W2947500857 creator A5020849201 @default.
• W2947500857 creator A5027845920 @default.
• W2947500857 creator A5029679813 @default.
• W2947500857 creator A5048320322 @default.
• W2947500857 creator A5057267382 @default.
• W2947500857 creator A5066141547 @default.
• W2947500857 creator A5066933299 @default.
• W2947500857 creator A5082969451 @default.
• W2947500857 creator A5088267604 @default.
• W2947500857 date "2019-05-30" @default.
• W2947500857 modified "2023-10-13" @default.
• W2947500857 title "Uric acid transporters BCRP and MRP4 involved in chickens uric acid excretion" @default.
• W2947500857 cites W1559080727 @default.
• W2947500857 cites W1818140528 @default.
• W2947500857 cites W1910056530 @default.
• W2947500857 cites W1968808580 @default.
• W2947500857 cites W1970359870 @default.
• W2947500857 cites W2002116300 @default.
• W2947500857 cites W2004061676 @default.
• W2947500857 cites W2005531240 @default.
• W2947500857 cites W2012790369 @default.
• W2947500857 cites W2031118520 @default.
• W2947500857 cites W2032614864 @default.
• W2947500857 cites W2044444556 @default.
• W2947500857 cites W2051167270 @default.
• W2947500857 cites W2052471911 @default.
• W2947500857 cites W2064983670 @default.
• W2947500857 cites W2070972281 @default.
• W2947500857 cites W2071730213 @default.
• W2947500857 cites W2074222717 @default.
• W2947500857 cites W2077652765 @default.
• W2947500857 cites W2082748546 @default.
• W2947500857 cites W2086459618 @default.
• W2947500857 cites W2092296126 @default.
• W2947500857 cites W2100808729 @default.
• W2947500857 cites W2122368675 @default.
• W2947500857 cites W2137423632 @default.
• W2947500857 cites W2142024216 @default.
• W2947500857 cites W2150866339 @default.
• W2947500857 cites W2160320288 @default.
• W2947500857 cites W2161789882 @default.
• W2947500857 cites W2166505632 @default.
• W2947500857 cites W2177303388 @default.
• W2947500857 cites W2289794603 @default.
• W2947500857 cites W2314984968 @default.
• W2947500857 cites W2319039640 @default.
• W2947500857 cites W2410837627 @default.
• W2947500857 cites W2516675614 @default.
• W2947500857 cites W2558564959 @default.
• W2947500857 cites W2575402762 @default.
• W2947500857 cites W2576559149 @default.
• W2947500857 cites W2626305073 @default.
• W2947500857 cites W2733852024 @default.
• W2947500857 cites W2765393780 @default.
• W2947500857 cites W2766662952 @default.
• W2947500857 cites W2779236266 @default.
• W2947500857 cites W2803169137 @default.
• W2947500857 doi "https://doi.org/10.1186/s12917-019-1886-9" @default.
• W2947500857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6543625" @default.
• W2947500857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31146764" @default.
• W2947500857 hasPublicationYear "2019" @default.
• W2947500857 type Work @default.
• W2947500857 sameAs 2947500857 @default.
• W2947500857 citedByCount "6" @default.
• W2947500857 countsByYear W29475008572020 @default.
• W2947500857 countsByYear W29475008572021 @default.
• W2947500857 countsByYear W29475008572022 @default.
• W2947500857 countsByYear W29475008572023 @default.
• W2947500857 crossrefType "journal-article" @default.
• W2947500857 hasAuthorship W2947500857A5006397924 @default.
• W2947500857 hasAuthorship W2947500857A5015358679 @default.
• W2947500857 hasAuthorship W2947500857A5016526551 @default.
• W2947500857 hasAuthorship W2947500857A5020849201 @default.
• W2947500857 hasAuthorship W2947500857A5027845920 @default.
• W2947500857 hasAuthorship W2947500857A5029679813 @default.
• W2947500857 hasAuthorship W2947500857A5048320322 @default.
• W2947500857 hasAuthorship W2947500857A5057267382 @default.
• W2947500857 hasAuthorship W2947500857A5066141547 @default.
• W2947500857 hasAuthorship W2947500857A5066933299 @default.
• W2947500857 hasAuthorship W2947500857A5082969451 @default.
• W2947500857 hasAuthorship W2947500857A5088267604 @default.
• W2947500857 hasBestOaLocation W29475008571 @default.
• W2947500857 hasConcept C10146269 @default.
• W2947500857 hasConcept C104317684 @default.
• W2947500857 hasConcept C126322002 @default.
• W2947500857 hasConcept C134018914 @default.
• W2947500857 hasConcept C149011108 @default.
• W2947500857 hasConcept C185592680 @default.
• W2947500857 hasConcept C2777226302 @default.
• W2947500857 hasConcept C2778024521 @default.
• W2947500857 hasConcept C2778176769 @default.
• W2947500857 hasConcept C2779306644 @default.
• W2947500857 hasConcept C2779881121 @default.
• W2947500857 hasConcept C2780091579 @default.
• W2947500857 hasConcept C2780306776 @default.

• next