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• W2947515856 abstract "The mouse primary visual cortex (V1) has become an important brain area for exploring how neural circuits process information. Optogenetic tools have helped to outline the connectivity of a local V1 circuit comprising excitatory pyramidal neurons and several genetically-defined inhibitory interneuron subtypes that express parvalbumin, somatostatin, or vasoactive intestinal peptide. Optogenetic modulation of individual interneuron subtypes can alter the visual responsiveness of pyramidal neurons with distinct forms of inhibition and disinhibition. However, different interneuron subtypes have potentially opposing actions, and the potency of their effects relative to each other remains unclear. Therefore, in this study we simultaneously optogenetically activated all interneuron subtypes during visual processing to explore whether any single inhibitory effect would predominate. This aggregate interneuron activation consistently inhibited pyramidal neurons in a divisive manner, which was essentially identical to the pattern of inhibition produced by activating parvalbumin-expressing interneurons alone." @default.
• W2947515856 created "2019-06-07" @default.
• W2947515856 creator A5012396069 @default.
• W2947515856 creator A5030977049 @default.
• W2947515856 creator A5043469671 @default.
• W2947515856 date "2019-05-28" @default.
• W2947515856 modified "2023-09-26" @default.
• W2947515856 title "Divisive Inhibition Prevails During Simultaneous Optogenetic Activation of All Interneuron Subtypes in Mouse Primary Visual Cortex" @default.
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• W2947515856 doi "https://doi.org/10.3389/fncir.2019.00040" @default.
• W2947515856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6546973" @default.
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• W2947515856 hasPublicationYear "2019" @default.
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