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- W2947524478 abstract "Abstract It has been suggested the subjective sense of certainty, or confidence, in ambiguous sensory cues can alter the interpretation of reward feedback and facilitate learning. We trained rats to report the orientation of ambiguous visual stimuli according to a spatial stimulus-response rule. Following choice, rats could wait a self-timed delay for reward or initiate a new trial. Waiting times increased with discrimination accuracy, demonstrating that this measure could be used as a proxy for confidence. Chemogenetic silencing of BLA shortened waiting times overall whereas ACC inhibition rendered waiting times insensitive to confidence-modulating attributes of visual stimuli, suggesting contribution of ACC but not BLA to confidence computations. Subsequent reversal learning was enhanced by confidence. Both ACC and BLA inhibition blocked this enhancement but via differential modulation of learning strategies and consistency in using learned rules. Altogether, we demonstrate dissociable roles for ACC and BLA in transmitting confidence and learning under uncertainty." @default.
- W2947524478 created "2019-06-07" @default.
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- W2947524478 date "2019-05-30" @default.
- W2947524478 modified "2023-10-01" @default.
- W2947524478 title "Dissociable roles for Anterior Cingulate Cortex and Basolateral Amygdala in Decision Confidence and Learning under Uncertainty" @default.
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- W2947524478 doi "https://doi.org/10.1101/655860" @default.
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