Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947536170> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2947536170 abstract "e15126 Background: Metastatic colorectal cancer (MCRC) survival has been improved in the last decade due to the identification of predictive and prognostic factors such as RAS gene status and also by the addition of targeted therapies to chemotherapy schemes. RAS mutation, a prognostic factor but must importantly a predictive factor for tumor response to monoclonal antibodies against the epidermal growth factor receptor in MCRC, has been reported between 16.3% and 43.6%. The aim of this study is to determine the frequency of RAS mutations in patients with MCRC in Central America and the Caribbean. Methods: This is a retrospective-descriptive analysis of RAS mutations performed in patients with MCRC in Central America and the Caribbean. An informed consent was required for the mutational analysis. The information obtained has been kept in an anonymized database. Results: 2,138 tissue samples were analyzed by real time PCR. RAS mutations were documented in 46.7% of the cases, of these 94.8% correspond to mutations in kRAS and 5.2% to mutations in nRAS. 67.5% of RAS mutations were found in codon 12, 21.3% in codon 13, 5.8% in codon 146 and 4% in codon 61. 51.5% of the mutations were in males and 48.5% in females. RAS mutations in central american population were identified in a 45.8% and in a 42.5% in the caribbean. Conclusions: This is the first report of RAS mutations in patients with MCRC in Central America and the Caribbean. Our findings are similar to the data reported in other regions of the world. A clinical and epidemiological analysis and correlation of these findings is underway." @default.
- W2947536170 created "2019-06-07" @default.
- W2947536170 creator A5001891305 @default.
- W2947536170 creator A5006664487 @default.
- W2947536170 creator A5006714677 @default.
- W2947536170 creator A5012276424 @default.
- W2947536170 creator A5013138939 @default.
- W2947536170 creator A5014445981 @default.
- W2947536170 creator A5021376751 @default.
- W2947536170 creator A5039229335 @default.
- W2947536170 creator A5058996066 @default.
- W2947536170 creator A5059122947 @default.
- W2947536170 creator A5059264103 @default.
- W2947536170 creator A5062096307 @default.
- W2947536170 creator A5062862103 @default.
- W2947536170 creator A5063957517 @default.
- W2947536170 creator A5068039027 @default.
- W2947536170 date "2019-05-20" @default.
- W2947536170 modified "2023-09-27" @default.
- W2947536170 title "RAS mutations in patients with metastatic colorectal cancer in Central America and the Caribbean." @default.
- W2947536170 doi "https://doi.org/10.1200/jco.2019.37.15_suppl.e15126" @default.
- W2947536170 hasPublicationYear "2019" @default.
- W2947536170 type Work @default.
- W2947536170 sameAs 2947536170 @default.
- W2947536170 citedByCount "0" @default.
- W2947536170 crossrefType "journal-article" @default.
- W2947536170 hasAuthorship W2947536170A5001891305 @default.
- W2947536170 hasAuthorship W2947536170A5006664487 @default.
- W2947536170 hasAuthorship W2947536170A5006714677 @default.
- W2947536170 hasAuthorship W2947536170A5012276424 @default.
- W2947536170 hasAuthorship W2947536170A5013138939 @default.
- W2947536170 hasAuthorship W2947536170A5014445981 @default.
- W2947536170 hasAuthorship W2947536170A5021376751 @default.
- W2947536170 hasAuthorship W2947536170A5039229335 @default.
- W2947536170 hasAuthorship W2947536170A5058996066 @default.
- W2947536170 hasAuthorship W2947536170A5059122947 @default.
- W2947536170 hasAuthorship W2947536170A5059264103 @default.
- W2947536170 hasAuthorship W2947536170A5062096307 @default.
- W2947536170 hasAuthorship W2947536170A5062862103 @default.
- W2947536170 hasAuthorship W2947536170A5063957517 @default.
- W2947536170 hasAuthorship W2947536170A5068039027 @default.
- W2947536170 hasConcept C121608353 @default.
- W2947536170 hasConcept C126322002 @default.
- W2947536170 hasConcept C143998085 @default.
- W2947536170 hasConcept C502942594 @default.
- W2947536170 hasConcept C526805850 @default.
- W2947536170 hasConcept C71924100 @default.
- W2947536170 hasConceptScore W2947536170C121608353 @default.
- W2947536170 hasConceptScore W2947536170C126322002 @default.
- W2947536170 hasConceptScore W2947536170C143998085 @default.
- W2947536170 hasConceptScore W2947536170C502942594 @default.
- W2947536170 hasConceptScore W2947536170C526805850 @default.
- W2947536170 hasConceptScore W2947536170C71924100 @default.
- W2947536170 hasLocation W29475361701 @default.
- W2947536170 hasOpenAccess W2947536170 @default.
- W2947536170 hasPrimaryLocation W29475361701 @default.
- W2947536170 hasRelatedWork W2093837066 @default.
- W2947536170 hasRelatedWork W2097943106 @default.
- W2947536170 hasRelatedWork W2156668530 @default.
- W2947536170 hasRelatedWork W2400137503 @default.
- W2947536170 hasRelatedWork W2569580755 @default.
- W2947536170 hasRelatedWork W2587975283 @default.
- W2947536170 hasRelatedWork W2890258973 @default.
- W2947536170 hasRelatedWork W2890483384 @default.
- W2947536170 hasRelatedWork W2892038127 @default.
- W2947536170 hasRelatedWork W2911032670 @default.
- W2947536170 hasRelatedWork W2947624033 @default.
- W2947536170 hasRelatedWork W2954009009 @default.
- W2947536170 hasRelatedWork W2998122162 @default.
- W2947536170 hasRelatedWork W3004883366 @default.
- W2947536170 hasRelatedWork W3029080106 @default.
- W2947536170 hasRelatedWork W3031347637 @default.
- W2947536170 hasRelatedWork W3041221595 @default.
- W2947536170 hasRelatedWork W3088090191 @default.
- W2947536170 hasRelatedWork W3123324424 @default.
- W2947536170 hasRelatedWork W3186299827 @default.
- W2947536170 isParatext "false" @default.
- W2947536170 isRetracted "false" @default.
- W2947536170 magId "2947536170" @default.
- W2947536170 workType "article" @default.