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- W2947554471 abstract "To elucidate the role and prognostic significance of lymphocyte activation-gene-3 (LAG-3) in soft tissue sarcoma (STS).The expression of LAG-3 in patient and matched normal blood samples was analyzed by flow cytometry. The localization and prognostic values of LAG-3+ cells in 163 STS patients were analyzed by immunohistochemistry. In addition, the expression of tumor-infiltrating CD3+ T, CD4+ T, and CD8+ T cells and their role in the prognosis of STS were evaluated by immunohistochemistry. The effect of LAG-3 blockade was evaluated in an immunocompetent MCA205 fibrosarcoma mouse model.Peripheral CD8+ and CD4+ T cells from STS patients expressed higher levels of LAG-3 than those from healthy donors. LAG-3 expression in STS was significantly associated with a poor clinical outcome (P = 0.038 ) and was correlated with high pathological grade (P < 0.001), advanced tumor stage ( P = 0.016). Additionally, LAG-3 expression was highly correlated with CD8+ T-cell infiltration (r = 0.7034, P < 0.001). LAG-3 was expressed in murine tumor-infiltrating lymphocytes, and its blockade decreased tumor growth and enhanced secretion of interferon-gamma by CD8 + and CD4+ T cells.LAG-3 blockade may be a promising strategy to improve the effects of targeted therapy in STS." @default.
- W2947554471 created "2019-06-07" @default.
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- W2947554471 date "2019-01-01" @default.
- W2947554471 modified "2023-10-09" @default.
- W2947554471 title "LAG-3 expression on tumor-infiltrating T cells in soft tissue sarcoma correlates with poor survival" @default.
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- W2947554471 doi "https://doi.org/10.20892/j.issn.2095-3941.2018.0306" @default.
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