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• W2947563583 abstract "Acute myeloid leukemia (AML) pertains to a hematologic malignancy with heterogeneous therapeutic responses. Improvements in risk stratification in AML patients are warranted. MicroRNAs have been associated with the pathogenesis of AML.To examine the prognostic value of miR-25, 162 cases with de novo AML were classified into two groups according to different treatment regimens.In the chemotherapy group, cases with upregulated miR-25 expression showed relatively longer overall survival (OS; P = 0.0086) and event-free survival (EFS; P = 0.019). Multivariable analyses revealed that miR-25 upregulation is an independent predictor for extended OS (HR = 0.556, P = 0.015) and EFS (HR = 0.598, P = 0.03). In addition, allogeneic hematopoietic stem cell transplantation (allo-HSCT) circumvented the poor prognosis that was related to miR-25 downregulation with chemotherapy. The expression level pattern of miR-25 coincided with AML differentiation and proliferation, which included HOXA and HOXB cluster members, as well as the HOX cofactor MEIS1. The MYH9 gene was identified as a direct target of miR-25.The miR-25 levels are correlated with prognosis in AML independently of other powerful molecular markers. The expression of miR-25 may contribute to the selection of the optimal treatment regimen between chemotherapy and allo-HCST for AML patients." @default.
• W2947563583 created "2019-06-07" @default.
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• W2947563583 date "2019-05-07" @default.
• W2947563583 modified "2023-10-16" @default.
• W2947563583 title "High expression of miR-25 predicts favorable chemotherapy outcome in patients with acute myeloid leukemia" @default.
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• W2947563583 doi "https://doi.org/10.1186/s12935-019-0843-9" @default.
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