FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947567107> ?p ?o ?g. }

• W2947567107 abstract "Differential diagnosis among psoriatic arthritis (PsA) and seronegative rheumatoid arthritis (Abneg RA) can be challenging particularly in the clinical setting of peripheral phenotype and autoantibodies seronegativity. The aim of the study was to identify synovial tissue (ST) biomarkers differentially expressed in PsA and Abneg RA and test their predictive value of therapeutic response. Thirty-four PsA patients [12 DMARD naive and 22 non-responder to methotrexate (MTX-IR)] with peripheral joint involvement and 55 Abneg RA (27 DMARD naive and 28 MTX-IR) underwent US-guided ST biopsy and immunohistochemistry (IHC) for CD68+, CD3+, CD20+, CD21+, CD117+, and CD138+ cells. After study entry, each DMARD-naive patient started MTX therapy and was followed in an outpatient setting for at least 6 months to define the achievement of Minimal Disease Activity (PsA) and DAS remission (Abneg RA) status respectively. Each IR-MTX patient was treated according to EULAR recommendations. At study entry, IHC analysis revealed that PsA patients had comparable levels of lining and sublining CD68+ and sublining CD21+, CD20+, and CD3+ cells than Abneg RA, despite the therapeutic regimen. Moreover, regardless of the therapeutic scheme, PsA patients showed higher IHC score of CD117+ cells (p = 0.0004 and p = 0.0005 for naive and MTX-IR patients respectively) compared to Abneg RA patients. Conversely, Abneg RA patients showed higher IHC score of CD138+ cells, irrespective to the therapeutic scheme (p = 0.04 and p = 0.002 for naive and MTX-IR patients respectively). Analyzing the response rate to the therapeutic scheme, naive PsA patients reaching MDA status at 6 months follow-up, showed, at the study entry, lower IHC score of CD3+ cells compared to PsA patients not reaching this outcome (p = 0.02); conversely, naive Abneg RA patients reaching DAS remission status at 6 months follow-up, showed, at the study entry, lower IHC score of sublining CD68+ cells compared to Abneg RA patients not reaching this outcome (p < 0.001). CD117+ and CD138+ cells are differentially distributed among PsA and Abneg RA. Histological analysis of ST may help to solve the clinical overlap between the two diseases and provides prognostic data about the therapy success." @default.
• W2947567107 created "2019-06-07" @default.
• W2947567107 creator A5007952296 @default.
• W2947567107 creator A5008032415 @default.
• W2947567107 creator A5008500196 @default.
• W2947567107 creator A5013878143 @default.
• W2947567107 creator A5021325586 @default.
• W2947567107 creator A5040269127 @default.
• W2947567107 creator A5045989939 @default.
• W2947567107 creator A5055735434 @default.
• W2947567107 creator A5059017027 @default.
• W2947567107 creator A5066368809 @default.
• W2947567107 creator A5081875091 @default.
• W2947567107 creator A5085647114 @default.
• W2947567107 date "2019-05-09" @default.
• W2947567107 modified "2023-10-07" @default.
• W2947567107 title "Differential synovial tissue biomarkers among psoriatic arthritis and rheumatoid factor/anti-citrulline antibody-negative rheumatoid arthritis" @default.
• W2947567107 cites W1515219927 @default.
• W2947567107 cites W181666549 @default.
• W2947567107 cites W1855295630 @default.
• W2947567107 cites W1964722637 @default.
• W2947567107 cites W1972413207 @default.
• W2947567107 cites W1998924700 @default.
• W2947567107 cites W2037192832 @default.
• W2947567107 cites W2042136358 @default.
• W2947567107 cites W2059529519 @default.
• W2947567107 cites W2077744324 @default.
• W2947567107 cites W2078197399 @default.
• W2947567107 cites W2079175701 @default.
• W2947567107 cites W2083180635 @default.
• W2947567107 cites W2093317470 @default.
• W2947567107 cites W2095947548 @default.
• W2947567107 cites W2098308083 @default.
• W2947567107 cites W2101005621 @default.
• W2947567107 cites W2104669609 @default.
• W2947567107 cites W2106036990 @default.
• W2947567107 cites W2113717019 @default.
• W2947567107 cites W2119989769 @default.
• W2947567107 cites W2120393706 @default.
• W2947567107 cites W2132981126 @default.
• W2947567107 cites W2152810939 @default.
• W2947567107 cites W2156796142 @default.
• W2947567107 cites W2157076874 @default.
• W2947567107 cites W2167643233 @default.
• W2947567107 cites W2169551148 @default.
• W2947567107 cites W2194197257 @default.
• W2947567107 cites W2580329215 @default.
• W2947567107 cites W2735347267 @default.
• W2947567107 cites W2779288713 @default.
• W2947567107 cites W2805352942 @default.
• W2947567107 cites W2806678383 @default.
• W2947567107 cites W2888114826 @default.
• W2947567107 cites W2890855006 @default.
• W2947567107 cites W2902459260 @default.
• W2947567107 cites W4211111012 @default.
• W2947567107 cites W4249063051 @default.
• W2947567107 cites W4295125684 @default.
• W2947567107 doi "https://doi.org/10.1186/s13075-019-1898-7" @default.
• W2947567107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6509792" @default.
• W2947567107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31072400" @default.
• W2947567107 hasPublicationYear "2019" @default.
• W2947567107 type Work @default.
• W2947567107 sameAs 2947567107 @default.
• W2947567107 citedByCount "19" @default.
• W2947567107 countsByYear W29475671072019 @default.
• W2947567107 countsByYear W29475671072020 @default.
• W2947567107 countsByYear W29475671072021 @default.
• W2947567107 countsByYear W29475671072022 @default.
• W2947567107 countsByYear W29475671072023 @default.
• W2947567107 crossrefType "journal-article" @default.
• W2947567107 hasAuthorship W2947567107A5007952296 @default.
• W2947567107 hasAuthorship W2947567107A5008032415 @default.
• W2947567107 hasAuthorship W2947567107A5008500196 @default.
• W2947567107 hasAuthorship W2947567107A5013878143 @default.
• W2947567107 hasAuthorship W2947567107A5021325586 @default.
• W2947567107 hasAuthorship W2947567107A5040269127 @default.
• W2947567107 hasAuthorship W2947567107A5045989939 @default.
• W2947567107 hasAuthorship W2947567107A5055735434 @default.
• W2947567107 hasAuthorship W2947567107A5059017027 @default.
• W2947567107 hasAuthorship W2947567107A5066368809 @default.
• W2947567107 hasAuthorship W2947567107A5081875091 @default.
• W2947567107 hasAuthorship W2947567107A5085647114 @default.
• W2947567107 hasBestOaLocation W29475671071 @default.
• W2947567107 hasConcept C126322002 @default.
• W2947567107 hasConcept C143998085 @default.
• W2947567107 hasConcept C159654299 @default.
• W2947567107 hasConcept C163764329 @default.
• W2947567107 hasConcept C18031839 @default.
• W2947567107 hasConcept C198451711 @default.
• W2947567107 hasConcept C203014093 @default.
• W2947567107 hasConcept C204232928 @default.
• W2947567107 hasConcept C2776232647 @default.
• W2947567107 hasConcept C2776260265 @default.
• W2947567107 hasConcept C2777575956 @default.
• W2947567107 hasConcept C2781059491 @default.
• W2947567107 hasConcept C71924100 @default.
• W2947567107 hasConcept C90924648 @default.
• W2947567107 hasConceptScore W2947567107C126322002 @default.
• W2947567107 hasConceptScore W2947567107C143998085 @default.
• W2947567107 hasConceptScore W2947567107C159654299 @default.

• next