FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947574880> ?p ?o ?g. }

• W2947574880 abstract "Deregulation of protein translation control is a hallmark of cancers. Eukaryotic initiation factor 4A2 (EIF4A2) is required for mRNA binding to ribosome and plays an important role in translation initiation. However, little is known about its functions in colorectal cancer (CRC). Analysis of CRC transcriptome data from TCGA identified that EIF4A2 was associated with poor prognosis. Immunohistochemistry study of EIF4A2 was carried out in 297 paired colorectal tumor and adjacent normal tissue samples. In vitro and in vivo cell-biological assays were performed to study the biological functions of EIF4A2 on experimental metastasis and sensitivity to oxaliplatin treatment. Bioinformatic prediction, chromatin immunoprecipitation (ChIP) and dual-luciferase reporter assay were carried out to unveil the transcription factor of EIF4A2 regulation. EIF4A2 Expression is significantly higher in colorectal tumors. Multivariate analysis suggests EIF4A2 as an independent predictor of overall, disease-free and progression-free survival. Dysfunction of EIF4A2 by genetic knock-down or small-molecule inhibitor silvestrol dramatically inhibited CRC invasion and migration, sphere formation and enhanced sensitivity to oxaliplatin treatment in vitro and in vivo. Notably, EIF4A2 knock-down also suppressed lung metastasis in vivo. qRT-PCR and immunoblotting analyses identified c-Myc as a downstream target and effector of EIF4A2. ChIP and dual-luciferase reporter assays validated the bioinformatical prediction of ZNF143 as a specific transcription factor of EIF4A2. EIF4A2 promotes experimental metastasis and oxaliplatin resistance in CRC. Silvestrol inhibits tumor growth and has synergistic effects with oxaliplatin to induce apoptosis in cell-derived xenograft (CDX) and patient-derived xenograft (PDX) models." @default.
• W2947574880 created "2019-06-07" @default.
• W2947574880 creator A5015939335 @default.
• W2947574880 creator A5025420008 @default.
• W2947574880 creator A5027890976 @default.
• W2947574880 creator A5035621752 @default.
• W2947574880 creator A5037015805 @default.
• W2947574880 creator A5039188196 @default.
• W2947574880 creator A5039370488 @default.
• W2947574880 creator A5041386762 @default.
• W2947574880 creator A5047517793 @default.
• W2947574880 creator A5049999064 @default.
• W2947574880 creator A5061817335 @default.
• W2947574880 creator A5061977873 @default.
• W2947574880 creator A5067433800 @default.
• W2947574880 creator A5072296344 @default.
• W2947574880 creator A5075846774 @default.
• W2947574880 creator A5081401106 @default.
• W2947574880 date "2019-05-14" @default.
• W2947574880 modified "2023-10-17" @default.
• W2947574880 title "Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer" @default.
• W2947574880 cites W1454765678 @default.
• W2947574880 cites W1940241680 @default.
• W2947574880 cites W1965163574 @default.
• W2947574880 cites W1966992478 @default.
• W2947574880 cites W1972250842 @default.
• W2947574880 cites W2005176113 @default.
• W2947574880 cites W2040885133 @default.
• W2947574880 cites W2045424472 @default.
• W2947574880 cites W2055163056 @default.
• W2947574880 cites W2067024190 @default.
• W2947574880 cites W2076089982 @default.
• W2947574880 cites W2089519503 @default.
• W2947574880 cites W2096184369 @default.
• W2947574880 cites W2121025268 @default.
• W2947574880 cites W2123472930 @default.
• W2947574880 cites W2128453465 @default.
• W2947574880 cites W2145502099 @default.
• W2947574880 cites W2159104053 @default.
• W2947574880 cites W2164693584 @default.
• W2947574880 cites W223909586 @default.
• W2947574880 cites W2272984102 @default.
• W2947574880 cites W2300010382 @default.
• W2947574880 cites W2400990766 @default.
• W2947574880 cites W2417426823 @default.
• W2947574880 cites W2438149348 @default.
• W2947574880 cites W2474079873 @default.
• W2947574880 cites W2520931866 @default.
• W2947574880 cites W2544544592 @default.
• W2947574880 cites W2607292654 @default.
• W2947574880 cites W2611101867 @default.
• W2947574880 cites W2611233292 @default.
• W2947574880 cites W2738737902 @default.
• W2947574880 cites W2739511077 @default.
• W2947574880 cites W2761878954 @default.
• W2947574880 cites W2766139357 @default.
• W2947574880 cites W2784104701 @default.
• W2947574880 cites W2789563811 @default.
• W2947574880 cites W2792746145 @default.
• W2947574880 cites W2797394051 @default.
• W2947574880 cites W2806421539 @default.
• W2947574880 cites W2883731008 @default.
• W2947574880 cites W2889891767 @default.
• W2947574880 cites W2890872797 @default.
• W2947574880 cites W2892730253 @default.
• W2947574880 cites W2898336689 @default.
• W2947574880 cites W2903973932 @default.
• W2947574880 cites W2911188335 @default.
• W2947574880 doi "https://doi.org/10.1186/s13046-019-1178-z" @default.
• W2947574880 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6518650" @default.
• W2947574880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31088567" @default.
• W2947574880 hasPublicationYear "2019" @default.
• W2947574880 type Work @default.
• W2947574880 sameAs 2947574880 @default.
• W2947574880 citedByCount "32" @default.
• W2947574880 countsByYear W29475748802019 @default.
• W2947574880 countsByYear W29475748802020 @default.
• W2947574880 countsByYear W29475748802021 @default.
• W2947574880 countsByYear W29475748802022 @default.
• W2947574880 countsByYear W29475748802023 @default.
• W2947574880 crossrefType "journal-article" @default.
• W2947574880 hasAuthorship W2947574880A5015939335 @default.
• W2947574880 hasAuthorship W2947574880A5025420008 @default.
• W2947574880 hasAuthorship W2947574880A5027890976 @default.
• W2947574880 hasAuthorship W2947574880A5035621752 @default.
• W2947574880 hasAuthorship W2947574880A5037015805 @default.
• W2947574880 hasAuthorship W2947574880A5039188196 @default.
• W2947574880 hasAuthorship W2947574880A5039370488 @default.
• W2947574880 hasAuthorship W2947574880A5041386762 @default.
• W2947574880 hasAuthorship W2947574880A5047517793 @default.
• W2947574880 hasAuthorship W2947574880A5049999064 @default.
• W2947574880 hasAuthorship W2947574880A5061817335 @default.
• W2947574880 hasAuthorship W2947574880A5061977873 @default.
• W2947574880 hasAuthorship W2947574880A5067433800 @default.
• W2947574880 hasAuthorship W2947574880A5072296344 @default.
• W2947574880 hasAuthorship W2947574880A5075846774 @default.
• W2947574880 hasAuthorship W2947574880A5081401106 @default.
• W2947574880 hasBestOaLocation W29475748801 @default.
• W2947574880 hasConcept C101762097 @default.
• W2947574880 hasConcept C104317684 @default.

• next