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• W2947583106 abstract "ABSTRACT Most women with epithelial ovarian cancer (EOC) present with late-stage disease. As a result, globally, EOC is responsible for more than 150,000 deaths a year. Thus, a better understanding of risk factors for developing EOC is crucial for earlier screening and detection to improve survival. To that effort, there have been suggestions that there is an association of schizophrenia and cancer possibly because metabolic changes are a hallmark of both cancer and schizophrenia (SZ). Perturbed choline metabolism has been documented in both diseases. Our objective was to use Mendelian randomization to evaluate whether SZ increased risk for developing EOC or the converse, and, whether SZ impacted glycerophosphocholine (GPC) metabolites. We found that SZ conferred a weak but significantly increased risk for EOC, but not the reverse (no evidence that EOC caused SZ), and that SZ was causally associated with lower levels of two GPC species and with suggestively lower levels in an additional three GPCs. We postulate that perturbed choline metabolism in SZ may mimic or contribute to a ‘cholinic’ phenotype, as observed in EOC cells." @default.
• W2947583106 created "2019-06-07" @default.
• W2947583106 creator A5062123247 @default.
• W2947583106 creator A5073472643 @default.
• W2947583106 date "2019-05-31" @default.
• W2947583106 modified "2023-09-25" @default.
• W2947583106 title "Epithelial ovarian cancer and schizophrenia and schizophrenia on circulating glycerophosphocholine metabolites: a Mendelian randomization study" @default.
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• W2947583106 hasPublicationYear "2019" @default.
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