FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947591153> ?p ?o ?g. }

• W2947591153 abstract "Abstract Telomerase negative immortal cancer cells elongate telomeres through the Alternative Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is required to maintain ALT, it might also lead to cell death when excessive. Here, we show that the ATPase/translocase activity of FANCM keeps telomeric replicative stress in check specifically in ALT cells. When FANCM is depleted in ALT cells, telomeres become dysfunctional, and cells stop proliferating and die. FANCM depletion also increases ALT-associated marks and de novo synthesis of telomeric DNA. Depletion of the BLM helicase reduces the telomeric replication stress and cell proliferation defects induced by FANCM inactivation. Finally, FANCM unwinds telomeric R-loops in vitro and suppresses their accumulation in cells. Overexpression of RNaseH1 completely abolishes the replication stress remaining in cells codepleted for FANCM and BLM. Thus, FANCM allows controlled ALT activity and ALT cell proliferation by limiting the toxicity of uncontrolled BLM and telomeric R-loops." @default.
• W2947591153 created "2019-06-07" @default.
• W2947591153 creator A5007142734 @default.
• W2947591153 creator A5015722085 @default.
• W2947591153 creator A5017683596 @default.
• W2947591153 creator A5019877272 @default.
• W2947591153 creator A5034316080 @default.
• W2947591153 creator A5045177184 @default.
• W2947591153 creator A5062411430 @default.
• W2947591153 creator A5075741748 @default.
• W2947591153 creator A5079986344 @default.
• W2947591153 date "2019-05-28" @default.
• W2947591153 modified "2023-10-14" @default.
• W2947591153 title "FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops" @default.
• W2947591153 cites W1562677361 @default.
• W2947591153 cites W1600373583 @default.
• W2947591153 cites W1622924446 @default.
• W2947591153 cites W1972655555 @default.
• W2947591153 cites W1972984145 @default.
• W2947591153 cites W1976736675 @default.
• W2947591153 cites W1977871027 @default.
• W2947591153 cites W1979324654 @default.
• W2947591153 cites W1982199027 @default.
• W2947591153 cites W1983636802 @default.
• W2947591153 cites W1983711411 @default.
• W2947591153 cites W1985214157 @default.
• W2947591153 cites W1986277376 @default.
• W2947591153 cites W1987369038 @default.
• W2947591153 cites W1989300604 @default.
• W2947591153 cites W1998491954 @default.
• W2947591153 cites W1999626396 @default.
• W2947591153 cites W2000971601 @default.
• W2947591153 cites W2013073993 @default.
• W2947591153 cites W2015946135 @default.
• W2947591153 cites W2016357039 @default.
• W2947591153 cites W2017948235 @default.
• W2947591153 cites W2021881561 @default.
• W2947591153 cites W2030976397 @default.
• W2947591153 cites W2034747770 @default.
• W2947591153 cites W2039641528 @default.
• W2947591153 cites W2046461941 @default.
• W2947591153 cites W2050128145 @default.
• W2947591153 cites W2073031672 @default.
• W2947591153 cites W2073204556 @default.
• W2947591153 cites W2080961638 @default.
• W2947591153 cites W2087967916 @default.
• W2947591153 cites W2096048754 @default.
• W2947591153 cites W2104493050 @default.
• W2947591153 cites W2107175910 @default.
• W2947591153 cites W2108674745 @default.
• W2947591153 cites W2112664493 @default.
• W2947591153 cites W2117459935 @default.
• W2947591153 cites W2117602431 @default.
• W2947591153 cites W2118991749 @default.
• W2947591153 cites W2132587601 @default.
• W2947591153 cites W2136986586 @default.
• W2947591153 cites W2137832223 @default.
• W2947591153 cites W2140336382 @default.
• W2947591153 cites W2140944222 @default.
• W2947591153 cites W2141288561 @default.
• W2947591153 cites W2141444502 @default.
• W2947591153 cites W2145344158 @default.
• W2947591153 cites W2152508214 @default.
• W2947591153 cites W2164313152 @default.
• W2947591153 cites W2192508404 @default.
• W2947591153 cites W2263990041 @default.
• W2947591153 cites W2270112503 @default.
• W2947591153 cites W2483130463 @default.
• W2947591153 cites W2509506469 @default.
• W2947591153 cites W2532728099 @default.
• W2947591153 cites W2532734448 @default.
• W2947591153 cites W2554310780 @default.
• W2947591153 cites W2558772818 @default.
• W2947591153 cites W2570439282 @default.
• W2947591153 cites W2581468657 @default.
• W2947591153 cites W2733026364 @default.
• W2947591153 cites W2740697669 @default.
• W2947591153 cites W2745330422 @default.
• W2947591153 cites W2746871201 @default.
• W2947591153 cites W2752110414 @default.
• W2947591153 cites W2759748330 @default.
• W2947591153 cites W2765655531 @default.
• W2947591153 cites W2777625864 @default.
• W2947591153 cites W2788748926 @default.
• W2947591153 cites W2914968800 @default.
• W2947591153 doi "https://doi.org/10.1038/s41467-019-10179-z" @default.
• W2947591153 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6538666" @default.
• W2947591153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31138795" @default.
• W2947591153 hasPublicationYear "2019" @default.
• W2947591153 type Work @default.
• W2947591153 sameAs 2947591153 @default.
• W2947591153 citedByCount "120" @default.
• W2947591153 countsByYear W29475911532019 @default.
• W2947591153 countsByYear W29475911532020 @default.
• W2947591153 countsByYear W29475911532021 @default.
• W2947591153 countsByYear W29475911532022 @default.
• W2947591153 countsByYear W29475911532023 @default.
• W2947591153 crossrefType "journal-article" @default.
• W2947591153 hasAuthorship W2947591153A5007142734 @default.
• W2947591153 hasAuthorship W2947591153A5015722085 @default.

• next