Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947606110> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2947606110 abstract "Patients with human immunodeficiency virus (HIV) infection have a high risk of developing virally-mediated cancers. These tumors have several features that could make them vulnerable to immune checkpoint inhibitors (ICIs) including, but not limited to, increased expression of the CTLA-4 and PD-1 checkpoints on their CD4+ T cells. Even so, HIV-positive patients are generally excluded from immunotherapy cancer clinical trials due to safety concerns. Hence, only case series have been published regarding HIV-positive patients with cancer who received ICIs, but these reports of individuals with a variety of malignancies demonstrate that ICIs have significant activity, exceeding a 65% objective response rate in Kaposi sarcoma. Furthermore, high-grade immune toxicities occurred in fewer than 10% of treated patients. The existing data suggest that the underlying biologic mechanisms that mediate development of cancer in HIV-infected patients should render them susceptible to ICI treatment. Preliminary, albeit limited, clinical experience indicates that checkpoint blockade is both safe and efficacious in this setting. Additional clinical trials that include HIV-positive patients with cancer are urgently needed." @default.
- W2947606110 created "2019-06-07" @default.
- W2947606110 creator A5018145340 @default.
- W2947606110 creator A5053481267 @default.
- W2947606110 creator A5062107881 @default.
- W2947606110 creator A5085031013 @default.
- W2947606110 date "2019-05-22" @default.
- W2947606110 modified "2023-10-18" @default.
- W2947606110 title "Remembering the forgotten child: the role of immune checkpoint inhibition in patients with human immunod eficiency virus and cancer" @default.
- W2947606110 cites W1978436252 @default.
- W2947606110 cites W2053463299 @default.
- W2947606110 cites W2088541970 @default.
- W2947606110 cites W2153013045 @default.
- W2947606110 cites W2154012156 @default.
- W2947606110 cites W2339890238 @default.
- W2947606110 cites W2517439829 @default.
- W2947606110 cites W2585932789 @default.
- W2947606110 cites W2589072142 @default.
- W2947606110 cites W2626017415 @default.
- W2947606110 cites W2747774814 @default.
- W2947606110 cites W2754796303 @default.
- W2947606110 cites W2768429453 @default.
- W2947606110 cites W2890934903 @default.
- W2947606110 cites W2901185593 @default.
- W2947606110 cites W2905801399 @default.
- W2947606110 cites W2908054647 @default.
- W2947606110 cites W2911264428 @default.
- W2947606110 doi "https://doi.org/10.1186/s40425-019-0618-9" @default.
- W2947606110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6530036" @default.
- W2947606110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31113482" @default.
- W2947606110 hasPublicationYear "2019" @default.
- W2947606110 type Work @default.
- W2947606110 sameAs 2947606110 @default.
- W2947606110 citedByCount "7" @default.
- W2947606110 countsByYear W29476061102019 @default.
- W2947606110 countsByYear W29476061102020 @default.
- W2947606110 countsByYear W29476061102021 @default.
- W2947606110 countsByYear W29476061102022 @default.
- W2947606110 crossrefType "journal-article" @default.
- W2947606110 hasAuthorship W2947606110A5018145340 @default.
- W2947606110 hasAuthorship W2947606110A5053481267 @default.
- W2947606110 hasAuthorship W2947606110A5062107881 @default.
- W2947606110 hasAuthorship W2947606110A5085031013 @default.
- W2947606110 hasBestOaLocation W29476061101 @default.
- W2947606110 hasConcept C121608353 @default.
- W2947606110 hasConcept C126322002 @default.
- W2947606110 hasConcept C142724271 @default.
- W2947606110 hasConcept C143998085 @default.
- W2947606110 hasConcept C170493617 @default.
- W2947606110 hasConcept C203014093 @default.
- W2947606110 hasConcept C2777701055 @default.
- W2947606110 hasConcept C2778256501 @default.
- W2947606110 hasConcept C2778468042 @default.
- W2947606110 hasConcept C2780674031 @default.
- W2947606110 hasConcept C2780851360 @default.
- W2947606110 hasConcept C3013748606 @default.
- W2947606110 hasConcept C535046627 @default.
- W2947606110 hasConcept C71924100 @default.
- W2947606110 hasConcept C8891405 @default.
- W2947606110 hasConceptScore W2947606110C121608353 @default.
- W2947606110 hasConceptScore W2947606110C126322002 @default.
- W2947606110 hasConceptScore W2947606110C142724271 @default.
- W2947606110 hasConceptScore W2947606110C143998085 @default.
- W2947606110 hasConceptScore W2947606110C170493617 @default.
- W2947606110 hasConceptScore W2947606110C203014093 @default.
- W2947606110 hasConceptScore W2947606110C2777701055 @default.
- W2947606110 hasConceptScore W2947606110C2778256501 @default.
- W2947606110 hasConceptScore W2947606110C2778468042 @default.
- W2947606110 hasConceptScore W2947606110C2780674031 @default.
- W2947606110 hasConceptScore W2947606110C2780851360 @default.
- W2947606110 hasConceptScore W2947606110C3013748606 @default.
- W2947606110 hasConceptScore W2947606110C535046627 @default.
- W2947606110 hasConceptScore W2947606110C71924100 @default.
- W2947606110 hasConceptScore W2947606110C8891405 @default.
- W2947606110 hasIssue "1" @default.
- W2947606110 hasLocation W29476061101 @default.
- W2947606110 hasLocation W29476061102 @default.
- W2947606110 hasLocation W29476061103 @default.
- W2947606110 hasLocation W29476061104 @default.
- W2947606110 hasLocation W29476061105 @default.
- W2947606110 hasOpenAccess W2947606110 @default.
- W2947606110 hasPrimaryLocation W29476061101 @default.
- W2947606110 hasRelatedWork W2171095535 @default.
- W2947606110 hasRelatedWork W2497869747 @default.
- W2947606110 hasRelatedWork W2612738915 @default.
- W2947606110 hasRelatedWork W2797580541 @default.
- W2947606110 hasRelatedWork W2820886885 @default.
- W2947606110 hasRelatedWork W2899537551 @default.
- W2947606110 hasRelatedWork W3129917327 @default.
- W2947606110 hasRelatedWork W3199051113 @default.
- W2947606110 hasRelatedWork W3204147903 @default.
- W2947606110 hasRelatedWork W4360983034 @default.
- W2947606110 hasVolume "7" @default.
- W2947606110 isParatext "false" @default.
- W2947606110 isRetracted "false" @default.
- W2947606110 magId "2947606110" @default.
- W2947606110 workType "article" @default.